Fruit Juices Can Worsen Drug Therapy

Author: Dean Rouseberg Time for reading: ~0 minutes Last Updated: August 08, 2022

Grapefruit, orange or apple juice can reduce the absorption of some drugs, affecting their effect, warn Canadians.

Grapefruit, orange or apple juice can reduce the absorption of some drugs, affecting their effect, warn Canadians. Among the medications used are used heart failure (beta-blockers), organ transplantation (cyclosporine), infections (quinolones) and others. David Bailey, a professor of clinical pharmacology at the University of Western Ontario, also announced years ago the role of grapefruit juice in improving the absorption of certain medications, which would lead to intoxication.

A clinical study among volunteers looked at the effect of citrus juice, as well as a solution of naringin (a component of said juice) or just water, on the absorption of an antihistamine used in allergic conditions. It is established that it is naringina that performs the blocking. However, the same fruit juice can increase the absorption of other drugs, but they block enzymes involved in the disposal of some drugs, thus increasing their concentration and toxic effect.

Fruit Juices Can Worsen Drug Therapy

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