Author: Mark Velov
Time for reading: ~1
minutes
Last Updated:
August 08, 2022
The drug fatostatin reduces the accumulation of fat in the body and at the same time stimulates it to release energy from the food consumed.
Scientists conducting experimental studies to synthesize an anti-obesity drug have developed a drug that not only helps reduce weight, but controls diabetes and lowers cholesterol.
The drug fatostatin reduces the accumulation of fat in the body and at the same time stimulates it to release energy from the food consumed.
Fatostatin acts on so-called SREBPs, which activate genes involved in the production of cholesterol and fatty acids. Fatostatin blocks weight gain, blood glucose rise and hepatic fat accumulation in genetically obese experimental animals, even with unrestricted food intake. Genetic tests show that the drug affects 63 different genes.
The researchers hope the new drug will help treat obesity, diabetes and cholesterol at the same time.
The study's leaders, Salih Waqil of Texas College of Medicine Baylor and Motonari Uesugi of Kyoto University in Japan, reported that the drug interacted with a number of genes triggered by overeating.
The researchers explained that the hormone leptin, which causes mice to lose weight, did not have the same effect on humans. However, they hope that photostatin will have the desired effect on overweight patients.
Walkil and his team have already patented the drug and are looking for a pharmaceutical company to develop it.
The researchers also reported that the drug had a positive effect on prostate cancer cells, which may help explain the observed links between prostate cancer and obesity.