1 Gm

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They had been basically denied, with the FDA pronouncing that the proof was “very restricted and preliminary,” with no endorsement allowed for ketchup or dietary supplements.

By that time, further populace stories had cast doubt on the lycopene theory. Consumers of excessive dietary intakes of lycopene didn’t seem to have lower most cancers rates, in any case.

But, who has high dietary intakes of lycopene?

Those that consume the maximum pizza; so, maybe it’s no surprise there are mixed consequences.

What we want is to position lycopene to the take a look at.

It started with a case research. A 62-yr vintage man with terminal prostate most cancers;

failed surgical treatment, failed chemotherapy, metastases all over, unfold to the bone.

And so, he become sent to hospice to die. So, he took it upon himself to provoke “phytotherapy”—plant-primarily based therapy, taking the amount of lycopene located in 1 / 4-cup of tomato sauce, or a tablespoon of tomato paste each day.

His PSA, a measure of tumor bulk, began out at 365, dropped to 140 the next month, and then down to 8.

His metastases began disappearing, and, as of his final comply with-up, seemed to be living luckily ever after. But, when given within higher-dose pill shape, it didn’t appear to paintings.

A 2013 evaluation of all such lycopene supplement trials “did not support [the initial] optimism.” In truth, they were simply satisfied that the lycopene capsules didn’t grow to be causing extra most cancers, like beta-carotene capsules did.

But, then came 2014. Researchers in Italy have been giving the most important doses they could of lycopene, selenium, and remoted green tea compounds to guys with precancerous prostate lesions, hoping they may save you complete-blown most cancers.

But, within 2014, the accelerated outcomes of a comparable trial had been published, in which selenium and nutrition E dietary supplements resulted in more cancer.

Yikes! So, these researchers stopped their trial, and broke the code to unblind the outcomes, And certainly, the ones taking high doses of lycopene, green tea catechins, and selenium seemed to get extra most cancers than people who simply got sugar pills.

“The ability implications are dramatic,” said the lead researcher, “given the modern-day huge international use of such compounds as alleged preventive supplementations in prostate and other cancers.” What went wrong?

Well, after the beta-carotene tablet debacle, researchers measured cellular damage at specific herbal and unnatural doses of beta-carotene. At nutritional doses, beta-carotene suppressed cellular harm, however at higher, supplemental doses, it now not best appeared to forestall working, however triggered extra harm.

And, the identical with lycopene.

“Both lycopene and [beta]-carotene afforded protection in opposition to DNA damage” at the varieties of stages one may see in human beings eating lots of tomatoes or sweet potatoes—”tiers…similar with the ones seen inside the [blood] of people who devour a carotenoid-rich wholesome weight loss program.” However, at the sort of blood concentrations that one would possibly get taking drugs, “the capacity to protect the cells in opposition to such [free radical] harm was swiftly lost, and, indeed, the presence of [high levels of beta-carotene and lycopene] may also simply serve to increase the quantity of DNA harm.” So, no surprise excessive-dose lycopene capsules didn’t paintings. “Phytochemicals [may be] guardians of our fitness,” but “[t]he protection of ingesting focused extracts…is unknown.” The protective benefits of a phytochemical-rich weight-reduction plan is best obtained [through whole plant foods].” The food enterprise has different thoughts, although.