Antioxidants Free Radicals

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But, lycopene within supplement shape doesn’t appear to be powerful at lower doses, both.

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“There is a sturdy [protective] correlation between the intake of [actual whole] fruit[s] and greens and the prevalence of certain cancers.” But when we complement with most effective a unmarried compound remoted within pill form, we can also disillusioned the healthy natural balance of antioxidants. It does appear to be quite the human hubris to think we can reproduce “the useful effects of eating entire end result and greens” by means of giving dietary supplements of a single phytochemical, which would commonly engage with hundreds of different compounds in “the herbal matrix” Mother Nature intended.

In addition to lycopene, different carotenoids within tomatoes encompass beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of which might be regarded “to accumulate within human prostate tissue.” And, “there are also severa non–carotenoid compounds within tomatoes that [may] have [anti-cancer] interest”—no longer to mention all the compounds we have yet to even signify.

But, it’s no longer approximately locating the one magic bullet: “The anti-most cancers consequences of carotenoids and other phytonutrients can also reside in [their] combined interest.” For example, at the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene observed in the general public who consume everyday amounts of tomatoes, there’s very little impact on cancer mobile boom within vitro, used one at a time.

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But combine them all together, and a non-effective dose plus a non-powerful dose will become effective by some means, significantly suppressing prostate most cancers cell increase.

And, the equal synergy can be visible throughout foods. Curcumin, the yellow pigment in turmeric and curry powder, tomato extracts, and the nutrition E found in nuts and seeds do little to inhibit seasoned-increase signaling of prostate most cancers cells—less than 10%.

But all three together suppresses growth signaling like 70%.

The whole is extra than the sum of its components.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty- sufferers with localized prostate [cancer]” were given three-quarters of a cup of canned tomato sauce each day “for three weeks…before their scheduled radical prostatectomy.” In their bloodstream, PSA stages dropped “with the aid of 17.5%.” PSA, prostate-specific antigen, is a protein produced by means of prostate gland cells, and accelerated blood ranges are routinely used “to display the success of [cancer] remedy.

It became unexpected to find that,” in just three weeks, a “tomato sauce-primarily based dietary intervention” may want to lower PSA concentrations in guys with prostate most cancers. Also, unfastened radical damage of the DNA in their white blood cells dropped by means of 21%.

Imagine how antioxidant-negative their diet ought to were ahead, if less than a cup of tomato sauce an afternoon ought to reduce DNA harm by using more than a 5th.

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Okay, however what did they find of their prostates? “[H]uman prostate tissue [is thought to] be particularly vulnerable to oxidative DNA damage by way of unfastened radicals, that are thought to play a essential function within all degrees of [cancer formation].” This may be for a number of motives, inclusive of “fewer DNA repair enzymes.” Well, the researchers had tissue samples taken before the tomato sauce from biopsies, and tissue samples after the 3 weeks of tomato sauce from the surgical treatment, and resected tissues from tomato sauce-supplemented patients had 28% much less free radical damage than predicted.

Here’s the DNA harm in the prostate before the tomato sauce, and here’s after.

Just 20 days of sauce. And, what’s thrilling is that “[t]right here changed into no affiliation between” the level of lycopene within the prostate and the protecting results.

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Tomatoes contain a whole bunch of things, some of which may be even more effective than lycopene.

Regardless, within comparison to the lycopene dietary supplements by myself, “the whole-meals intervention” appeared to help. To see if lycopene played any role at all, one would have to test a lycopene-unfastened tomato—within different words, a yellow tomato.

So, what in case you in comparison crimson tomatoes to yellow tomatoes, which have all of the non-lycopene tomato compounds, to directly lycopene within a pill?

So, they fed human beings pink tomato paste, yellow tomato paste, lycopene capsules, or placebo capsules, after which dripped their blood on prostate most cancers cells growing within a petri dish.

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Compared to those no longer ingesting something, the purple tomato serum, the blood from people who ate purple tomato paste, significantly reduced the prostate most cancers cellular’s expression of a boom-promoting gene known as cyclin D1.

This downregulation of the gene by means of the purple tomato intake “may also make a contribution to decrease prostate cancer hazard through restricting cell proliferation.” The crimson tomato seemed to paintings better than the yellow;

so, perhaps the lycopene helped, but now not within tablet form. “[T]his gene changed into no longer regulated by using [the lycopene-pill serum],” indicating that maybe it’s something else.

And, lycopene by myself appreciably upregulated “procarcinogenic genes.

Antioxidants And Free Radicals Ppt