Best Antioxidant Supplement

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But, lycopene in complement form doesn’t appear to be effective at decrease doses, either.

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“There is a strong [protective] correlation among the intake of [actual whole] fruit[s] and greens and the occurrence of positive cancers.” But when we supplement with best a single compound isolated in pill form, we may additionally disappointed the healthy herbal stability of antioxidants. It does seem to be pretty the human hubris to assume we are able to reproduce “the useful outcomes of ingesting entire culmination and vegetables” by using giving dietary supplements of a single phytochemical, which could typically have interaction with hundreds of other compounds in “the herbal matrix” Mother Nature supposed.

In addition to lycopene, different carotenoids within tomatoes include beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of that are recognized “to accumulate in human prostate tissue.” And, “there also are numerous non–carotenoid compounds in tomatoes that [may] have [anti-cancer] activity”—not to say all of the compounds we have yet to even symbolize.

But, it’s not approximately finding the one magic bullet: “The anti-cancer results of carotenoids and other phytonutrients may are living within [their] blended interest.” For instance, on the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene observed within most of the people who consume normal quantities of tomatoes, there’s little or no impact on most cancers mobile increase within vitro, used one by one.

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But combine all of them collectively, and a non-effective dose plus a non-effective dose becomes effective by some means, substantially suppressing prostate cancer cellular increase.

And, the identical synergy may be seen across foods. Curcumin, the yellow pigment in turmeric and curry powder, tomato extracts, and the nutrition E discovered within nuts and seeds do little to inhibit pro-growth signaling of prostate most cancers cells—less than 10%.

But all three together suppresses growth signaling like 70%.

The whole is greater than the sum of its components.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty- sufferers with localized prostate [cancer]” have been given three-quarters of a cup of canned tomato sauce each day “for three weeks…earlier than their scheduled radical prostatectomy.” In their bloodstream, PSA stages dropped “with the aid of 17.5%.” PSA, prostate-particular antigen, is a protein produced by using prostate gland cells, and expanded blood stages are automatically used “to monitor the fulfillment of [cancer] remedy.

It was unexpected to locate that,” in just three weeks, a “tomato sauce-based totally nutritional intervention” may want to decrease PSA concentrations in men with prostate most cancers. Also, loose radical damage of the DNA in their white blood cells dropped by 21%.

Imagine how antioxidant-negative their eating regimen need to had been in advance, if less than a cup of tomato sauce a day could reduce DNA harm by using greater than a 5th.

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Okay, however what did they find of their prostates? “[H]uman prostate tissue [is thought to] be particularly prone to oxidative DNA damage by loose radicals, which are thought to play a essential position within all stages of [cancer formation].” This can be for a number of motives, including “fewer DNA restore enzymes.” Well, the researchers had tissue samples taken before the tomato sauce from biopsies, and tissue samples after the three weeks of tomato sauce from the surgical treatment, and resected tissues from tomato sauce-supplemented sufferers had 28% much less free radical harm than anticipated.

Here’s the DNA damage in the prostate before the tomato sauce, and here’s after.

Just 20 days of sauce. And, what’s exciting is that “[t]right here was no association between” the level of lycopene inside the prostate and the protective results.

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Tomatoes comprise an entire bunch of things, some of which can be even extra effective than lycopene.

Regardless, within comparison to the lycopene dietary supplements on my own, “the entire-food intervention” seemed to assist. To see if lycopene played any position in any respect, one would have to test a lycopene-free tomato—within different phrases, a yellow tomato.

So, what if you compared crimson tomatoes to yellow tomatoes, which have all of the non-lycopene tomato compounds, to straight lycopene within a tablet?

So, they fed humans pink tomato paste, yellow tomato paste, lycopene pills, or placebo tablets, and then dripped their blood on prostate cancer cells growing in a petri dish.

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Compared to those not ingesting anything, the red tomato serum, the blood from individuals who ate purple tomato paste, substantially decreased the prostate most cancers mobile’s expression of a increase-selling gene referred to as cyclin D1.

This downregulation of the gene by the crimson tomato intake “might also contribute to lower prostate most cancers chance by means of proscribing cellular proliferation.” The pink tomato appeared to work higher than the yellow;

so, maybe the lycopene helped, however not within tablet form. “[T]his gene turned into no longer regulated with the aid of [the lycopene-pill serum],” indicating that perhaps it’s some thing else.

And, lycopene by myself appreciably upregulated “procarcinogenic genes.

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