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But, lycopene in supplement form doesn’t appear like effective at decrease doses, both.

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“There is a strong [protective] correlation between the consumption of [actual whole] fruit[s] and vegetables and the occurrence of sure cancers.” But when we supplement with only a unmarried compound isolated within tablet shape, we can also disenchanted the wholesome herbal balance of antioxidants. It does seem to be pretty the human hubris to suppose we can reproduce “the useful consequences of consuming complete end result and greens” via giving supplements of a unmarried phytochemical, which could commonly interact with thousands of different compounds in “the natural matrix” Mother Nature supposed.

In addition to lycopene, different carotenoids in tomatoes consist of beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of that are acknowledged “to accumulate within human prostate tissue.” And, “there also are severa non–carotenoid compounds within tomatoes that [may] have [anti-cancer] pastime”—now not to say all of the compounds we've got but to even signify.

But, it’s no longer approximately finding the only magic bullet: “The anti-most cancers consequences of carotenoids and other phytonutrients might also are living within [their] blended activity.” For instance, on the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene found within most people who eat everyday amounts of tomatoes, there’s very little impact on cancer cellular boom within vitro, used one after the other.

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But integrate them all together, and a non-powerful dose plus a non-powerful dose becomes powerful in some way, appreciably suppressing prostate most cancers cellular growth.

And, the identical synergy may be visible throughout ingredients. Curcumin, the yellow pigment in turmeric and curry powder, tomato extracts, and the nutrition E determined within nuts and seeds do little to inhibit pro-boom signaling of prostate most cancers cells—less than 10%.

But all three together suppresses increase signaling like 70%.

The entire is extra than the sum of its parts.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty-two sufferers with localized prostate [cancer]” have been given three-quarters of a cup of canned tomato sauce each day “for 3 weeks…earlier than their scheduled radical prostatectomy.” In their bloodstream, PSA tiers dropped “by using 17.5%.” PSA, prostate-specific antigen, is a protein produced with the aid of prostate gland cells, and multiplied blood levels are automatically used “to screen the achievement of [cancer] remedy.

It changed into surprising to find that,” in only three weeks, a “tomato sauce-based nutritional intervention” may want to lower PSA concentrations within guys with prostate most cancers. Also, unfastened radical harm of the DNA in their white blood cells dropped by 21%.

Imagine how antioxidant-bad their weight-reduction plan need to had been beforehand, if much less than a cup of tomato sauce a day ought to lessen DNA harm through extra than a 5th.

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Okay, but what did they locate in their prostates? “[H]uman prostate tissue [is thought to] be in particular prone to oxidative DNA harm by way of unfastened radicals, which are concept to play a vital role within all ranges of [cancer formation].” This may be for a number of reasons, consisting of “fewer DNA repair enzymes.” Well, the researchers had tissue samples taken before the tomato sauce from biopsies, and tissue samples after the three weeks of tomato sauce from the surgical procedure, and resected tissues from tomato sauce-supplemented patients had 28% much less free radical harm than predicted.

Here’s the DNA damage in the prostate earlier than the tomato sauce, and here’s after.

Just 20 days of sauce. And, what’s thrilling is that “[t]right here became no affiliation between” the extent of lycopene within the prostate and the protecting effects.

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Tomatoes incorporate an entire bunch of things, some of which can be even extra effective than lycopene.

Regardless, within evaluation to the lycopene dietary supplements alone, “the entire-meals intervention” regarded to assist. To see if lycopene performed any position at all, one would have to check a lycopene-free tomato—in other words, a yellow tomato.

So, what if you compared purple tomatoes to yellow tomatoes, that have all of the non-lycopene tomato compounds, to straight lycopene within a tablet?

So, they fed humans pink tomato paste, yellow tomato paste, lycopene tablets, or placebo tablets, after which dripped their blood on prostate most cancers cells developing within a petri dish.

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Compared to those no longer ingesting some thing, the red tomato serum, the blood from those who ate purple tomato paste, significantly reduced the prostate most cancers cell’s expression of a boom-promoting gene known as cyclin D1.

This downregulation of the gene by using the pink tomato intake “may also contribute to decrease prostate cancer risk by means of proscribing cell proliferation.” The red tomato regarded to paintings higher than the yellow;

so, maybe the lycopene helped, however now not in tablet shape. “[T]his gene become no longer regulated by using [the lycopene-pill serum],” indicating that maybe it’s something else.

And, lycopene alone considerably upregulated “procarcinogenic genes.

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