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But, lycopene within supplement shape doesn’t seem like powerful at decrease doses, both.

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“There is a strong [protective] correlation between the consumption of [actual whole] fruit[s] and greens and the prevalence of certain cancers.” But while we complement with simplest a unmarried compound isolated within tablet form, we might also dissatisfied the healthful herbal stability of antioxidants. It does seem to be pretty the human hubris to assume we will reproduce “the beneficial effects of ingesting whole fruits and veggies” with the aid of giving dietary supplements of a unmarried phytochemical, which might normally have interaction with heaps of other compounds within “the natural matrix” Mother Nature intended.

In addition to lycopene, different carotenoids in tomatoes include beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of which are regarded “to build up within human prostate tissue.” And, “there also are numerous non–carotenoid compounds within tomatoes that [may] have [anti-cancer] pastime”—not to mention all of the compounds we've yet to even characterize.

But, it’s not approximately locating the one magic bullet: “The anti-cancer outcomes of carotenoids and different phytonutrients may additionally live within [their] combined hobby.” For example, at the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene found in most of the people who eat normal quantities of tomatoes, there’s very little effect on cancer mobile increase within vitro, used one by one.

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But integrate them all together, and a non-effective dose plus a non-powerful dose will become powerful by hook or by crook, notably suppressing prostate most cancers mobile boom.

And, the equal synergy may be visible throughout meals. Curcumin, the yellow pigment within turmeric and curry powder, tomato extracts, and the vitamin E discovered within nuts and seeds do little to inhibit seasoned-growth signaling of prostate most cancers cells—less than 10%.

But all three collectively suppresses boom signaling like 70%.

The whole is more than the sum of its parts.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty-two sufferers with localized prostate [cancer]” had been given three-quarters of a cup of canned tomato sauce every day “for 3 weeks…earlier than their scheduled radical prostatectomy.” In their bloodstream, PSA degrees dropped “by using 17.5%.” PSA, prostate-precise antigen, is a protein produced via prostate gland cells, and extended blood stages are robotically used “to display the success of [cancer] remedy.

It turned into surprising to locate that,” in just three weeks, a “tomato sauce-based nutritional intervention” ought to decrease PSA concentrations within men with prostate most cancers. Also, loose radical damage of the DNA in their white blood cells dropped with the aid of 21%.

Imagine how antioxidant-poor their weight-reduction plan must have been beforehand, if less than a cup of tomato sauce an afternoon could lessen DNA damage by way of more than a fifth.

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Okay, but what did they discover in their prostates? “[H]uman prostate tissue [is thought to] be mainly vulnerable to oxidative DNA damage by means of loose radicals, which might be notion to play a critical role within all levels of [cancer formation].” This can be for some of reasons, including “fewer DNA restore enzymes.” Well, the researchers had tissue samples taken before the tomato sauce from biopsies, and tissue samples after the three weeks of tomato sauce from the surgical operation, and resected tissues from tomato sauce-supplemented sufferers had 28% less loose radical harm than expected.

Here’s the DNA harm inside the prostate earlier than the tomato sauce, and here’s after.

Just 20 days of sauce. And, what’s thrilling is that “[t]right here became no affiliation between” the level of lycopene in the prostate and the protecting effects.

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Tomatoes incorporate a whole bunch of things, some of which can be even greater effective than lycopene.

Regardless, in evaluation to the lycopene supplements alone, “the whole-meals intervention” appeared to assist. To see if lycopene played any function in any respect, one would have to test a lycopene-free tomato—in other phrases, a yellow tomato.

So, what in case you in comparison red tomatoes to yellow tomatoes, which have all the non-lycopene tomato compounds, to directly lycopene within a pill?

So, they fed human beings purple tomato paste, yellow tomato paste, lycopene pills, or placebo pills, and then dripped their blood on prostate cancer cells developing in a petri dish.

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Compared to the ones now not ingesting some thing, the red tomato serum, the blood from folks who ate purple tomato paste, appreciably reduced the prostate most cancers cell’s expression of a boom-selling gene called cyclin D1.

This downregulation of the gene by means of the red tomato consumption “might also contribute to decrease prostate most cancers danger with the aid of proscribing mobile proliferation.” The pink tomato seemed to work better than the yellow;

so, perhaps the lycopene helped, however no longer within pill shape. “[T]his gene changed into not regulated by way of [the lycopene-pill serum],” indicating that maybe it’s some thing else.

And, lycopene on my own notably upregulated “procarcinogenic genes.

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