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They had been essentially denied, with the FDA pronouncing that the proof turned into “very restrained and preliminary,” and not using a endorsement allowed for ketchup or supplements.

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By that point, similarly population studies had solid doubt at the lycopene principle. Consumers of excessive nutritional intakes of lycopene didn’t appear to have lower most cancers shares, after all.

But, who has high dietary intakes of lycopene?

Those that consume the maximum pizza; so, perhaps it’s no marvel there are blended effects.

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What we want is to put lycopene to the test.

It commenced with a case study. A 62-yr vintage man with terminal prostate most cancers;

failed surgical treatment, failed chemotherapy, metastases all over, unfold to the bone.

And so, he changed into sent to hospice to die.

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So, he took it upon himself to initiate “phytotherapy”—plant-based totally remedy, taking the quantity of lycopene determined in 1 / 4-cup of tomato sauce, or a tablespoon of tomato paste each day.

His PSA, a measure of tumor bulk, started out at 365, dropped to 140 the following month, after which all the way down to 8.

His metastases started out disappearing, and, as of his remaining observe-up, appeared to be dwelling happily ever after. But, whilst given within better-dose tablet shape, it didn’t appear to paintings.

A 2013 review of all such lycopene complement trials “did not aid [the initial] optimism.” In reality, they were just satisfied that the lycopene capsules didn’t turn out to be causing more cancer, like beta-carotene tablets did.

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But, then came 2014. Researchers within Italy were giving the most important doses they could of lycopene, selenium, and isolated inexperienced tea compounds to men with precancerous prostate lesions, hoping they could save you full-blown most cancers.

But, within 2014, the increased consequences of a comparable trial have been posted, in which selenium and vitamin E supplements led to extra most cancers.

Yikes! So, those researchers stopped their trial, and broke the code to unblind the results, And certainly, the ones taking high doses of lycopene, inexperienced tea catechins, and selenium seemed to get more cancer than people who just got sugar drugs.

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“The capability implications are dramatic,” said the lead researcher, “given the present day big global use of such compounds as alleged preventive supplements within prostate and other cancers.” What went incorrect?

Well, after the beta-carotene tablet debacle, researchers measured cell harm at special natural and unnatural doses of beta-carotene. At nutritional doses, beta-carotene suppressed cell damage, however at higher, supplemental doses, it not handiest seemed to stop operating, but prompted more damage.

And, the same with lycopene.

“Both lycopene and [beta]-carotene afforded protection in opposition to DNA damage” at the styles of levels one might see in people ingesting plenty of tomatoes or candy potatoes—”tiers…comparable with those visible in the [blood] of folks that eat a carotenoid-rich healthful weight-reduction plan.” However, at the type of blood concentrations that one would possibly get taking capsules, “the ability to guard the cells against such [free radical] harm became unexpectedly lost, and, indeed, the presence of [high levels of beta-carotene and lycopene] may also honestly serve to boom the extent of DNA damage.” So, no wonder excessive-dose lycopene tablets didn’t work.

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“Phytochemicals [may be] guardians of our health,” but “[t]he safety of eating concentrated extracts…is unknown.” The protecting advantages of a phytochemical-wealthy weight loss plan is first-class received [through whole plant foods].” The meals enterprise has different thoughts, although.