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But, lycopene within complement form doesn’t look like powerful at lower doses, both.

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“There is a sturdy [protective] correlation between the consumption of [actual whole] fruit[s] and greens and the prevalence of sure cancers.” But while we complement with best a unmarried compound isolated within pill form, we may additionally upset the healthful herbal stability of antioxidants. It does appear to be pretty the human hubris to suppose we can reproduce “the useful consequences of ingesting entire end result and vegetables” via giving supplements of a single phytochemical, which might usually interact with lots of different compounds within “the natural matrix” Mother Nature intended.

In addition to lycopene, different carotenoids in tomatoes include beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of that are known “to build up in human prostate tissue.” And, “there also are severa non–carotenoid compounds in tomatoes that [may] have [anti-cancer] activity”—no longer to mention all the compounds we've got but to even characterize.

But, it’s no longer about finding the one magic bullet: “The anti-cancer results of carotenoids and different phytonutrients may additionally live within [their] combined interest.” For example, at the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene found in the general public who devour ordinary quantities of tomatoes, there’s very little impact on most cancers cell increase in vitro, used one by one.

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But combine them all together, and a non-effective dose plus a non-effective dose becomes effective by some means, appreciably suppressing prostate most cancers mobile growth.

And, the identical synergy may be visible throughout ingredients. Curcumin, the yellow pigment in turmeric and curry powder, tomato extracts, and the nutrition E located in nuts and seeds do little to inhibit pro-increase signaling of prostate most cancers cells—less than 10%.

But all three together suppresses boom signaling like 70%.

The whole is extra than the sum of its parts.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty- sufferers with localized prostate [cancer]” were given three-quarters of a cup of canned tomato sauce each day “for three weeks…earlier than their scheduled radical prostatectomy.” In their bloodstream, PSA tiers dropped “through 17.5%.” PSA, prostate-precise antigen, is a protein produced by means of prostate gland cells, and elevated blood levels are routinely used “to monitor the achievement of [cancer] treatment.

It become sudden to locate that,” in only three weeks, a “tomato sauce-primarily based dietary intervention” ought to decrease PSA concentrations in men with prostate cancer. Also, free radical damage of the DNA of their white blood cells dropped through 21%.

Imagine how antioxidant-negative their weight loss plan have to had been beforehand, if less than a cup of tomato sauce an afternoon should lessen DNA harm by means of extra than a 5th.

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Okay, but what did they find of their prostates? “[H]uman prostate tissue [is thought to] be mainly vulnerable to oxidative DNA damage with the aid of unfastened radicals, that are thought to play a crucial function within all levels of [cancer formation].” This may be for some of reasons, which include “fewer DNA restore enzymes.” Well, the researchers had tissue samples taken earlier than the tomato sauce from biopsies, and tissue samples after the 3 weeks of tomato sauce from the surgical operation, and resected tissues from tomato sauce-supplemented sufferers had 28% much less free radical damage than expected.

Here’s the DNA harm inside the prostate earlier than the tomato sauce, and right here’s after.

Just 20 days of sauce. And, what’s exciting is that “[t]here changed into no affiliation among” the extent of lycopene in the prostate and the protecting results.

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Tomatoes incorporate an entire bunch of things, a number of which may be even more powerful than lycopene.

Regardless, in evaluation to the lycopene supplements alone, “the complete-meals intervention” appeared to assist. To see if lycopene performed any position in any respect, one might have to test a lycopene-unfastened tomato—in different phrases, a yellow tomato.

So, what in case you as compared pink tomatoes to yellow tomatoes, that have all the non-lycopene tomato compounds, to instantly lycopene in a tablet?

So, they fed people purple tomato paste, yellow tomato paste, lycopene capsules, or placebo pills, and then dripped their blood on prostate cancer cells growing in a petri dish.

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Compared to the ones now not consuming something, the purple tomato serum, the blood from people who ate purple tomato paste, notably decreased the prostate most cancers cellular’s expression of a growth-selling gene known as cyclin D1.

This downregulation of the gene by the crimson tomato intake “can also make contributions to decrease prostate most cancers hazard by using proscribing cellular proliferation.” The red tomato appeared to paintings better than the yellow;

so, maybe the lycopene helped, however no longer within tablet form. “[T]his gene became not regulated via [the lycopene-pill serum],” indicating that perhaps it’s some thing else.

And, lycopene on my own extensively upregulated “procarcinogenic genes.

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