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But, lycopene in supplement form doesn’t appear to be powerful at decrease doses, either.

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“There is a sturdy [protective] correlation between the intake of [actual whole] fruit[s] and veggies and the incidence of certain cancers.” But while we complement with simplest a single compound remoted in pill shape, we may additionally disenchanted the healthy herbal balance of antioxidants. It does seem to be pretty the human hubris to suppose we will reproduce “the beneficial effects of consuming entire culmination and greens” through giving dietary supplements of a unmarried phytochemical, which would generally have interaction with lots of other compounds in “the natural matrix” Mother Nature supposed.

In addition to lycopene, other carotenoids in tomatoes include beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of which are regarded “to accumulate in human prostate tissue.” And, “there are also severa non–carotenoid compounds in tomatoes that [may] have [anti-cancer] interest”—now not to mention all the compounds we've yet to even characterize.

But, it’s not approximately finding the only magic bullet: “The anti-most cancers outcomes of carotenoids and other phytonutrients may also are living in [their] blended activity.” For instance, on the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene found within most people who devour normal quantities of tomatoes, there’s very little impact on most cancers cellular boom in vitro, used separately.

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But integrate all of them collectively, and a non-effective dose plus a non-powerful dose will become effective somehow, notably suppressing prostate most cancers mobile growth.

And, the identical synergy can be seen throughout meals. Curcumin, the yellow pigment in turmeric and curry powder, tomato extracts, and the vitamin E discovered in nuts and seeds do little to inhibit pro-boom signaling of prostate most cancers cells—less than 10%.

But all three collectively suppresses boom signaling like 70%.

The complete is more than the sum of its elements.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty-two patients with localized prostate [cancer]” had been given three-quarters of a cup of canned tomato sauce each day “for 3 weeks…earlier than their scheduled radical prostatectomy.” In their bloodstream, PSA levels dropped “through 17.5%.” PSA, prostate-precise antigen, is a protein produced by way of prostate gland cells, and multiplied blood stages are robotically used “to monitor the achievement of [cancer] treatment.

It turned into surprising to find that,” in only three weeks, a “tomato sauce-based dietary intervention” ought to lower PSA concentrations within guys with prostate cancer. Also, unfastened radical damage of the DNA in their white blood cells dropped by 21%.

Imagine how antioxidant-bad their food regimen must had been in advance, if much less than a cup of tomato sauce a day should reduce DNA damage by more than a fifth.

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Okay, however what did they locate in their prostates? “[H]uman prostate tissue [is thought to] be particularly susceptible to oxidative DNA damage by means of loose radicals, that are idea to play a essential role within all tiers of [cancer formation].” This may be for some of reasons, which includes “fewer DNA restore enzymes.” Well, the researchers had tissue samples taken earlier than the tomato sauce from biopsies, and tissue samples after the three weeks of tomato sauce from the surgery, and resected tissues from tomato sauce-supplemented patients had 28% less loose radical damage than expected.

Here’s the DNA damage within the prostate before the tomato sauce, and right here’s after.

Just 20 days of sauce. And, what’s exciting is that “[t]here turned into no affiliation among” the level of lycopene within the prostate and the protecting outcomes.

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Tomatoes contain an entire bunch of factors, some of which can be even more effective than lycopene.

Regardless, in contrast to the lycopene supplements alone, “the whole-meals intervention” seemed to assist. To see if lycopene played any function in any respect, one would have to test a lycopene-loose tomato—within different phrases, a yellow tomato.

So, what if you compared pink tomatoes to yellow tomatoes, that have all of the non-lycopene tomato compounds, to directly lycopene in a pill?

So, they fed humans pink tomato paste, yellow tomato paste, lycopene capsules, or placebo pills, and then dripped their blood on prostate cancer cells developing in a petri dish.

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Compared to the ones not consuming some thing, the purple tomato serum, the blood from folks that ate red tomato paste, notably reduced the prostate cancer mobile’s expression of a increase-promoting gene called cyclin D1.

This downregulation of the gene by way of the crimson tomato intake “can also make a contribution to decrease prostate cancer risk by way of restricting mobile proliferation.” The red tomato appeared to paintings higher than the yellow;

so, perhaps the lycopene helped, but not in pill form. “[T]his gene became no longer regulated by means of [the lycopene-pill serum],” indicating that perhaps it’s some thing else.

And, lycopene on my own significantly upregulated “procarcinogenic genes.

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