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But, lycopene in complement shape doesn’t appear to be effective at lower doses, either.

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“There is a robust [protective] correlation among the intake of [actual whole] fruit[s] and vegetables and the incidence of certain cancers.” But while we complement with only a unmarried compound isolated in tablet form, we may disillusioned the healthful natural balance of antioxidants. It does appear to be quite the human hubris to assume we are able to reproduce “the useful consequences of ingesting complete end result and vegetables” by using giving supplements of a unmarried phytochemical, which might normally interact with thousands of different compounds in “the herbal matrix” Mother Nature intended.

In addition to lycopene, different carotenoids in tomatoes encompass beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of which are recognized “to build up within human prostate tissue.” And, “there are also severa non–carotenoid compounds within tomatoes that [may] have [anti-cancer] interest”—no longer to say all the compounds we've but to even characterize.

But, it’s no longer about finding the one magic bullet: “The anti-cancer consequences of carotenoids and different phytonutrients may additionally live in [their] combined interest.” For example, at the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene located in most of the people who devour normal quantities of tomatoes, there’s little or no effect on cancer cell increase in vitro, used one at a time.

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But integrate them all together, and a non-powerful dose plus a non-powerful dose will become powerful one way or the other, significantly suppressing prostate cancer cell growth.

And, the identical synergy may be seen throughout meals. Curcumin, the yellow pigment within turmeric and curry powder, tomato extracts, and the vitamin E located in nuts and seeds do little to inhibit seasoned-boom signaling of prostate cancer cells—much less than 10%.

But all three together suppresses boom signaling like 70%.

The complete is greater than the sum of its parts.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty- sufferers with localized prostate [cancer]” have been given three-quarters of a cup of canned tomato sauce every day “for 3 weeks…earlier than their scheduled radical prostatectomy.” In their bloodstream, PSA tiers dropped “with the aid of 17.5%.” PSA, prostate-precise antigen, is a protein produced via prostate gland cells, and multiplied blood ranges are routinely used “to display the success of [cancer] remedy.

It became surprising to discover that,” in only three weeks, a “tomato sauce-based dietary intervention” ought to decrease PSA concentrations in men with prostate cancer. Also, unfastened radical damage of the DNA in their white blood cells dropped with the aid of 21%.

Imagine how antioxidant-poor their food plan ought to had been in advance, if less than a cup of tomato sauce an afternoon could reduce DNA damage via more than a 5th.

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Okay, but what did they discover of their prostates? “[H]uman prostate tissue [is thought to] be mainly prone to oxidative DNA damage by using free radicals, which are notion to play a critical position in all stages of [cancer formation].” This may be for some of reasons, which includes “fewer DNA restore enzymes.” Well, the researchers had tissue samples taken before the tomato sauce from biopsies, and tissue samples after the three weeks of tomato sauce from the surgery, and resected tissues from tomato sauce-supplemented sufferers had 28% less free radical damage than expected.

Here’s the DNA damage inside the prostate earlier than the tomato sauce, and here’s after.

Just 20 days of sauce. And, what’s thrilling is that “[t]here changed into no association among” the extent of lycopene within the prostate and the protecting outcomes.

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Tomatoes comprise a whole bunch of things, some of which may be even greater powerful than lycopene.

Regardless, in contrast to the lycopene supplements on my own, “the complete-food intervention” regarded to help. To see if lycopene played any position in any respect, one would have to test a lycopene-loose tomato—within different phrases, a yellow tomato.

So, what if you compared red tomatoes to yellow tomatoes, that have all the non-lycopene tomato compounds, to directly lycopene within a tablet?

So, they fed humans purple tomato paste, yellow tomato paste, lycopene pills, or placebo pills, after which dripped their blood on prostate cancer cells developing in a petri dish.

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Compared to the ones now not eating something, the crimson tomato serum, the blood from individuals who ate pink tomato paste, appreciably reduced the prostate cancer cell’s expression of a growth-selling gene called cyclin D1.

This downregulation of the gene via the crimson tomato intake “may additionally make a contribution to lower prostate most cancers chance by way of restricting cellular proliferation.” The crimson tomato regarded to work better than the yellow;

so, perhaps the lycopene helped, however no longer in tablet form. “[T]his gene changed into now not regulated with the aid of [the lycopene-pill serum],” indicating that maybe it’s some thing else.

And, lycopene on my own appreciably upregulated “procarcinogenic genes.

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