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But, lycopene within supplement form doesn’t look like effective at decrease doses, either.

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“There is a sturdy [protective] correlation between the consumption of [actual whole] fruit[s] and greens and the prevalence of sure cancers.” But when we complement with simplest a single compound isolated within tablet shape, we may additionally dissatisfied the healthy natural balance of antioxidants. It does appear to be quite the human hubris to assume we can reproduce “the beneficial effects of consuming complete end result and vegetables” via giving supplements of a single phytochemical, which could typically have interaction with hundreds of other compounds within “the natural matrix” Mother Nature intended.

In addition to lycopene, different carotenoids within tomatoes include beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of which are recognized “to accumulate within human prostate tissue.” And, “there are also severa non–carotenoid compounds in tomatoes that [may] have [anti-cancer] interest”—not to mention all of the compounds we have yet to even characterize.

But, it’s not about locating the one magic bullet: “The anti-cancer consequences of carotenoids and other phytonutrients may additionally are living within [their] combined interest.” For example, at the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene discovered in the majority who eat normal quantities of tomatoes, there’s very little impact on most cancers mobile boom within vitro, used one at a time.

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But integrate all of them together, and a non-effective dose plus a non-powerful dose turns into effective somehow, extensively suppressing prostate cancer cell growth.

And, the same synergy can be seen across meals. Curcumin, the yellow pigment within turmeric and curry powder, tomato extracts, and the vitamin E discovered within nuts and seeds do little to inhibit pro-growth signaling of prostate most cancers cells—less than 10%.

But all three together suppresses boom signaling like 70%.

The complete is more than the sum of its parts.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty- sufferers with localized prostate [cancer]” had been given three-quarters of a cup of canned tomato sauce each day “for 3 weeks…before their scheduled radical prostatectomy.” In their bloodstream, PSA stages dropped “via 17.5%.” PSA, prostate-particular antigen, is a protein produced through prostate gland cells, and increased blood degrees are robotically used “to screen the fulfillment of [cancer] treatment.

It became surprising to discover that,” in only three weeks, a “tomato sauce-based totally nutritional intervention” may want to lower PSA concentrations in guys with prostate most cancers. Also, loose radical damage of the DNA of their white blood cells dropped with the aid of 21%.

Imagine how antioxidant-negative their weight loss program have to have been in advance, if less than a cup of tomato sauce an afternoon ought to lessen DNA harm by using greater than a 5th.

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Okay, but what did they discover in their prostates? “[H]uman prostate tissue [is thought to] be particularly liable to oxidative DNA damage by unfastened radicals, which might be concept to play a critical position within all levels of [cancer formation].” This may be for a number of reasons, such as “fewer DNA restore enzymes.” Well, the researchers had tissue samples taken earlier than the tomato sauce from biopsies, and tissue samples after the three weeks of tomato sauce from the surgery, and resected tissues from tomato sauce-supplemented sufferers had 28% much less loose radical damage than expected.

Here’s the DNA damage inside the prostate before the tomato sauce, and right here’s after.

Just 20 days of sauce. And, what’s exciting is that “[t]right here was no association between” the level of lycopene inside the prostate and the protecting outcomes.

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Tomatoes include an entire bunch of things, a number of which may be even extra effective than lycopene.

Regardless, within comparison to the lycopene supplements by myself, “the complete-food intervention” regarded to assist. To see if lycopene performed any function in any respect, one could have to test a lycopene-unfastened tomato—within other words, a yellow tomato.

So, what in case you in comparison purple tomatoes to yellow tomatoes, which have all of the non-lycopene tomato compounds, to straight lycopene within a pill?

So, they fed people pink tomato paste, yellow tomato paste, lycopene tablets, or placebo tablets, and then dripped their blood on prostate most cancers cells developing in a petri dish.

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Compared to the ones no longer ingesting whatever, the red tomato serum, the blood from folks that ate crimson tomato paste, extensively reduced the prostate most cancers cellular’s expression of a boom-promoting gene referred to as cyclin D1.

This downregulation of the gene via the crimson tomato consumption “may also make contributions to lower prostate cancer danger by proscribing mobile proliferation.” The crimson tomato appeared to work better than the yellow;

so, maybe the lycopene helped, however not in pill shape. “[T]his gene was not regulated through [the lycopene-pill serum],” indicating that maybe it’s some thing else.

And, lycopene on my own drastically upregulated “procarcinogenic genes.

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