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But, lycopene in supplement shape doesn’t seem like powerful at decrease doses, either.

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“There is a robust [protective] correlation among the consumption of [actual whole] fruit[s] and vegetables and the incidence of positive cancers.” But while we supplement with best a single compound isolated in tablet shape, we may additionally disenchanted the healthy herbal stability of antioxidants. It does seem to be pretty the human hubris to suppose we are able to reproduce “the beneficial outcomes of consuming complete end result and veggies” by giving supplements of a unmarried phytochemical, which might normally engage with heaps of other compounds within “the herbal matrix” Mother Nature intended.

In addition to lycopene, other carotenoids within tomatoes include beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of which can be acknowledged “to accumulate within human prostate tissue.” And, “there are also numerous non–carotenoid compounds within tomatoes that [may] have [anti-cancer] activity”—now not to mention all the compounds we've yet to even symbolize.

But, it’s not approximately finding the only magic bullet: “The anti-most cancers consequences of carotenoids and different phytonutrients may also are living within [their] mixed activity.” For instance, on the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene located in most people who devour everyday quantities of tomatoes, there’s little or no effect on most cancers mobile increase in vitro, used separately.

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But combine all of them together, and a non-powerful dose plus a non-powerful dose becomes powerful one way or the other, extensively suppressing prostate most cancers cell growth.

And, the identical synergy may be visible across foods. Curcumin, the yellow pigment within turmeric and curry powder, tomato extracts, and the diet E discovered within nuts and seeds do little to inhibit pro-growth signaling of prostate most cancers cells—much less than 10%.

But all three together suppresses boom signaling like 70%.

The complete is more than the sum of its components.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty- sufferers with localized prostate [cancer]” have been given three-quarters of a cup of canned tomato sauce each day “for three weeks…before their scheduled radical prostatectomy.” In their bloodstream, PSA stages dropped “by using 17.5%.” PSA, prostate-unique antigen, is a protein produced by prostate gland cells, and elevated blood levels are robotically used “to screen the success of [cancer] treatment.

It was surprising to find that,” in just three weeks, a “tomato sauce-primarily based dietary intervention” may want to lower PSA concentrations within men with prostate most cancers. Also, free radical damage of the DNA of their white blood cells dropped by means of 21%.

Imagine how antioxidant-negative their weight loss program should have been ahead, if much less than a cup of tomato sauce a day could lessen DNA harm by way of extra than a fifth.

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Okay, however what did they discover in their prostates? “[H]uman prostate tissue [is thought to] be specially prone to oxidative DNA harm by means of loose radicals, which can be notion to play a critical function within all degrees of [cancer formation].” This may be for some of motives, such as “fewer DNA restore enzymes.” Well, the researchers had tissue samples taken earlier than the tomato sauce from biopsies, and tissue samples after the three weeks of tomato sauce from the surgical operation, and resected tissues from tomato sauce-supplemented patients had 28% less loose radical harm than predicted.

Here’s the DNA harm inside the prostate earlier than the tomato sauce, and here’s after.

Just 20 days of sauce. And, what’s interesting is that “[t]right here turned into no association among” the level of lycopene inside the prostate and the protecting results.

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Tomatoes contain an entire bunch of factors, some of which can be even more effective than lycopene.

Regardless, within contrast to the lycopene dietary supplements on my own, “the whole-meals intervention” seemed to help. To see if lycopene performed any function in any respect, one could have to check a lycopene-free tomato—within different words, a yellow tomato.

So, what in case you in comparison crimson tomatoes to yellow tomatoes, that have all of the non-lycopene tomato compounds, to instantly lycopene in a pill?

So, they fed people red tomato paste, yellow tomato paste, lycopene tablets, or placebo drugs, and then dripped their blood on prostate cancer cells growing within a petri dish.

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Compared to the ones now not eating whatever, the red tomato serum, the blood from folks who ate pink tomato paste, considerably decreased the prostate most cancers mobile’s expression of a growth-selling gene referred to as cyclin D1.

This downregulation of the gene through the purple tomato intake “may make a contribution to lower prostate cancer threat by way of proscribing cellular proliferation.” The red tomato regarded to work better than the yellow;

so, perhaps the lycopene helped, however now not in tablet shape. “[T]his gene became no longer regulated by means of [the lycopene-pill serum],” indicating that maybe it’s some thing else.

And, lycopene alone appreciably upregulated “procarcinogenic genes.

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