Beta Carotene Extract

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But, lycopene in supplement form doesn’t appear like effective at decrease doses, both.

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“There is a sturdy [protective] correlation between the intake of [actual whole] fruit[s] and veggies and the prevalence of certain cancers.” But whilst we supplement with only a unmarried compound isolated in pill form, we may disenchanted the healthy herbal balance of antioxidants. It does seem to be pretty the human hubris to suppose we will reproduce “the beneficial results of eating entire culmination and vegetables” by using giving supplements of a unmarried phytochemical, which could usually interact with thousands of different compounds in “the herbal matrix” Mother Nature meant.

In addition to lycopene, other carotenoids in tomatoes consist of beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of which can be regarded “to accumulate within human prostate tissue.” And, “there also are severa non–carotenoid compounds in tomatoes that [may] have [anti-cancer] pastime”—now not to say all of the compounds we have yet to even represent.

But, it’s now not about locating the only magic bullet: “The anti-most cancers outcomes of carotenoids and other phytonutrients can also are living within [their] blended pastime.” For example, at the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene observed within most of the people who devour normal amounts of tomatoes, there’s very little impact on most cancers cell increase in vitro, used one at a time.

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But combine all of them together, and a non-effective dose plus a non-effective dose will become powerful one way or the other, extensively suppressing prostate most cancers cellular increase.

And, the equal synergy can be seen throughout meals. Curcumin, the yellow pigment within turmeric and curry powder, tomato extracts, and the vitamin E discovered within nuts and seeds do little to inhibit pro-growth signaling of prostate most cancers cells—less than 10%.

But all three collectively suppresses growth signaling like 70%.

The whole is greater than the sum of its parts.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty- sufferers with localized prostate [cancer]” had been given three-quarters of a cup of canned tomato sauce each day “for 3 weeks…before their scheduled radical prostatectomy.” In their bloodstream, PSA degrees dropped “via 17.5%.” PSA, prostate-unique antigen, is a protein produced via prostate gland cells, and extended blood degrees are mechanically used “to screen the achievement of [cancer] treatment.

It became unexpected to discover that,” in only three weeks, a “tomato sauce-primarily based nutritional intervention” may want to decrease PSA concentrations within men with prostate cancer. Also, free radical harm of the DNA in their white blood cells dropped by way of 21%.

Imagine how antioxidant-negative their weight loss program have to have been ahead, if much less than a cup of tomato sauce an afternoon ought to lessen DNA harm via more than a fifth.

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Okay, however what did they locate in their prostates? “[H]uman prostate tissue [is thought to] be specifically vulnerable to oxidative DNA harm by using loose radicals, which might be idea to play a critical function within all degrees of [cancer formation].” This may be for some of motives, together with “fewer DNA restore enzymes.” Well, the researchers had tissue samples taken before the tomato sauce from biopsies, and tissue samples after the three weeks of tomato sauce from the surgical treatment, and resected tissues from tomato sauce-supplemented patients had 28% less loose radical harm than expected.

Here’s the DNA harm in the prostate before the tomato sauce, and right here’s after.

Just 20 days of sauce. And, what’s exciting is that “[t]right here become no affiliation among” the extent of lycopene in the prostate and the protecting effects.

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Tomatoes incorporate a whole bunch of things, a number of which may be even more effective than lycopene.

Regardless, within assessment to the lycopene supplements alone, “the whole-food intervention” regarded to help. To see if lycopene played any position at all, one could have to check a lycopene-free tomato—within different words, a yellow tomato.

So, what if you in comparison red tomatoes to yellow tomatoes, that have all of the non-lycopene tomato compounds, to straight lycopene in a tablet?

So, they fed human beings crimson tomato paste, yellow tomato paste, lycopene capsules, or placebo capsules, and then dripped their blood on prostate cancer cells developing within a petri dish.

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Compared to the ones not eating anything, the red tomato serum, the blood from folks that ate red tomato paste, considerably reduced the prostate most cancers cellular’s expression of a increase-selling gene known as cyclin D1.

This downregulation of the gene by using the pink tomato consumption “may additionally make a contribution to lower prostate most cancers threat by using restricting cellular proliferation.” The red tomato appeared to paintings higher than the yellow;

so, perhaps the lycopene helped, however not in tablet form. “[T]his gene changed into now not regulated with the aid of [the lycopene-pill serum],” indicating that perhaps it’s some thing else.

And, lycopene by myself appreciably upregulated “procarcinogenic genes.

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