Beta Carotene Vitamin C

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But, lycopene within supplement shape doesn’t look like effective at lower doses, either.

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“There is a strong [protective] correlation between the consumption of [actual whole] fruit[s] and greens and the incidence of positive cancers.” But while we complement with best a single compound remoted within tablet shape, we might also disappointed the healthful natural stability of antioxidants. It does seem to be pretty the human hubris to suppose we will reproduce “the beneficial consequences of eating entire fruits and veggies” by way of giving supplements of a unmarried phytochemical, which could normally engage with hundreds of different compounds in “the herbal matrix” Mother Nature supposed.

In addition to lycopene, other carotenoids in tomatoes encompass beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of that are regarded “to build up within human prostate tissue.” And, “there also are numerous non–carotenoid compounds within tomatoes that [may] have [anti-cancer] hobby”—now not to say all of the compounds we've yet to even signify.

But, it’s no longer about locating the only magic bullet: “The anti-most cancers results of carotenoids and different phytonutrients might also are living within [their] combined activity.” For instance, on the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene determined within most of the people who devour everyday amounts of tomatoes, there’s very little impact on cancer cellular increase within vitro, used one at a time.

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But combine all of them together, and a non-effective dose plus a non-effective dose becomes powerful by hook or by crook, notably suppressing prostate cancer mobile increase.

And, the equal synergy may be seen across meals. Curcumin, the yellow pigment in turmeric and curry powder, tomato extracts, and the vitamin E discovered within nuts and seeds do little to inhibit pro-increase signaling of prostate cancer cells—much less than 10%.

But all three together suppresses boom signaling like 70%.

The whole is more than the sum of its parts.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty-two patients with localized prostate [cancer]” were given three-quarters of a cup of canned tomato sauce each day “for three weeks…before their scheduled radical prostatectomy.” In their bloodstream, PSA levels dropped “by way of 17.5%.” PSA, prostate-particular antigen, is a protein produced by prostate gland cells, and multiplied blood ranges are robotically used “to reveal the achievement of [cancer] remedy.

It turned into sudden to find that,” in only three weeks, a “tomato sauce-primarily based dietary intervention” should lower PSA concentrations within men with prostate cancer. Also, free radical damage of the DNA in their white blood cells dropped with the aid of 21%.

Imagine how antioxidant-bad their diet ought to were in advance, if much less than a cup of tomato sauce a day should lessen DNA harm by greater than a fifth.

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Okay, but what did they locate of their prostates? “[H]uman prostate tissue [is thought to] be specially vulnerable to oxidative DNA harm by using loose radicals, which might be idea to play a important function in all ranges of [cancer formation].” This may be for some of motives, together with “fewer DNA restore enzymes.” Well, the researchers had tissue samples taken earlier than the tomato sauce from biopsies, and tissue samples after the three weeks of tomato sauce from the surgery, and resected tissues from tomato sauce-supplemented patients had 28% less unfastened radical harm than predicted.

Here’s the DNA damage inside the prostate earlier than the tomato sauce, and here’s after.

Just 20 days of sauce. And, what’s interesting is that “[t]here changed into no affiliation among” the extent of lycopene in the prostate and the protective consequences.

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Tomatoes include an entire bunch of things, some of which can be even extra effective than lycopene.

Regardless, in evaluation to the lycopene dietary supplements alone, “the entire-meals intervention” seemed to help. To see if lycopene played any function at all, one might have to check a lycopene-free tomato—within different phrases, a yellow tomato.

So, what if you compared pink tomatoes to yellow tomatoes, which have all the non-lycopene tomato compounds, to straight lycopene in a pill?

So, they fed human beings pink tomato paste, yellow tomato paste, lycopene drugs, or placebo capsules, after which dripped their blood on prostate cancer cells growing within a petri dish.

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Compared to the ones now not eating some thing, the red tomato serum, the blood from those who ate purple tomato paste, notably reduced the prostate cancer cellular’s expression of a growth-promoting gene called cyclin D1.

This downregulation of the gene by way of the purple tomato consumption “may also make contributions to decrease prostate most cancers hazard with the aid of restricting cellular proliferation.” The purple tomato regarded to work better than the yellow;

so, maybe the lycopene helped, however now not within tablet shape. “[T]his gene was not regulated with the aid of [the lycopene-pill serum],” indicating that perhaps it’s some thing else.

And, lycopene on my own substantially upregulated “procarcinogenic genes.

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