Curcumin Extract

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But, lycopene within supplement form doesn’t look like powerful at decrease doses, either.

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“There is a sturdy [protective] correlation among the consumption of [actual whole] fruit[s] and veggies and the occurrence of positive cancers.” But while we complement with handiest a single compound isolated within pill form, we can also dissatisfied the healthy herbal stability of antioxidants. It does appear to be pretty the human hubris to assume we are able to reproduce “the useful outcomes of consuming entire end result and veggies” through giving dietary supplements of a single phytochemical, which might typically interact with lots of other compounds within “the herbal matrix” Mother Nature supposed.

In addition to lycopene, different carotenoids within tomatoes encompass beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of which are acknowledged “to build up within human prostate tissue.” And, “there also are numerous non–carotenoid compounds in tomatoes that [may] have [anti-cancer] pastime”—no longer to mention all of the compounds we've got yet to even symbolize.

But, it’s not approximately locating the only magic bullet: “The anti-cancer outcomes of carotenoids and different phytonutrients may also live in [their] mixed hobby.” For instance, on the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene determined within most people who eat everyday quantities of tomatoes, there’s very little effect on most cancers cellular increase within vitro, used one at a time.

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But combine all of them collectively, and a non-powerful dose plus a non-powerful dose becomes powerful by some means, drastically suppressing prostate cancer cellular increase.

And, the equal synergy may be seen throughout foods. Curcumin, the yellow pigment within turmeric and curry powder, tomato extracts, and the vitamin E observed in nuts and seeds do little to inhibit seasoned-increase signaling of prostate cancer cells—less than 10%.

But all three collectively suppresses increase signaling like 70%.

The complete is extra than the sum of its elements.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty- patients with localized prostate [cancer]” have been given three-quarters of a cup of canned tomato sauce each day “for 3 weeks…earlier than their scheduled radical prostatectomy.” In their bloodstream, PSA degrees dropped “by way of 17.5%.” PSA, prostate-specific antigen, is a protein produced by prostate gland cells, and extended blood ranges are automatically used “to screen the achievement of [cancer] treatment.

It was surprising to locate that,” in only three weeks, a “tomato sauce-based totally nutritional intervention” should decrease PSA concentrations in men with prostate cancer. Also, unfastened radical harm of the DNA in their white blood cells dropped through 21%.

Imagine how antioxidant-poor their diet need to had been beforehand, if less than a cup of tomato sauce a day should lessen DNA harm via extra than a 5th.

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Okay, however what did they find of their prostates? “[H]uman prostate tissue [is thought to] be specifically at risk of oxidative DNA harm by free radicals, that are concept to play a essential position in all ranges of [cancer formation].” This may be for some of motives, consisting of “fewer DNA restore enzymes.” Well, the researchers had tissue samples taken before the tomato sauce from biopsies, and tissue samples after the three weeks of tomato sauce from the surgical operation, and resected tissues from tomato sauce-supplemented patients had 28% much less loose radical damage than anticipated.

Here’s the DNA damage in the prostate earlier than the tomato sauce, and right here’s after.

Just 20 days of sauce. And, what’s thrilling is that “[t]here turned into no affiliation among” the level of lycopene in the prostate and the protective results.

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Tomatoes contain an entire bunch of things, some of which can be even greater effective than lycopene.

Regardless, in assessment to the lycopene dietary supplements by myself, “the entire-meals intervention” seemed to help. To see if lycopene played any function in any respect, one might have to test a lycopene-unfastened tomato—in different words, a yellow tomato.

So, what if you in comparison crimson tomatoes to yellow tomatoes, which have all the non-lycopene tomato compounds, to straight lycopene within a pill?

So, they fed people pink tomato paste, yellow tomato paste, lycopene capsules, or placebo capsules, after which dripped their blood on prostate most cancers cells developing within a petri dish.

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Compared to the ones now not ingesting some thing, the red tomato serum, the blood from folks who ate pink tomato paste, significantly decreased the prostate most cancers cellular’s expression of a growth-selling gene known as cyclin D1.

This downregulation of the gene by means of the pink tomato consumption “may additionally contribute to lower prostate most cancers chance through limiting cell proliferation.” The purple tomato seemed to work higher than the yellow;

so, maybe the lycopene helped, but no longer within pill shape. “[T]his gene changed into no longer regulated with the aid of [the lycopene-pill serum],” indicating that perhaps it’s some thing else.

And, lycopene on my own considerably upregulated “procarcinogenic genes.

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