Do Antioxidants Work

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But, lycopene in supplement shape doesn’t look like effective at decrease doses, either.

Do Antioxidants Work On Skin

“There is a sturdy [protective] correlation among the consumption of [actual whole] fruit[s] and greens and the incidence of certain cancers.” But while we supplement with only a single compound remoted in tablet form, we may additionally disillusioned the healthy natural stability of antioxidants. It does appear to be pretty the human hubris to assume we can reproduce “the beneficial outcomes of ingesting complete culmination and veggies” via giving dietary supplements of a unmarried phytochemical, which could commonly have interaction with lots of different compounds within “the natural matrix” Mother Nature supposed.

In addition to lycopene, other carotenoids within tomatoes include beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of which can be recognized “to build up in human prostate tissue.” And, “there also are severa non–carotenoid compounds within tomatoes that [may] have [anti-cancer] activity”—not to say all the compounds we have but to even symbolize.

But, it’s no longer about locating the one magic bullet: “The anti-most cancers consequences of carotenoids and other phytonutrients may live in [their] mixed interest.” For example, on the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene located within the majority who consume ordinary quantities of tomatoes, there’s little or no impact on most cancers cellular growth in vitro, used one by one.

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But combine them all collectively, and a non-effective dose plus a non-powerful dose becomes powerful by some means, appreciably suppressing prostate cancer cell boom.

And, the identical synergy can be seen across foods. Curcumin, the yellow pigment within turmeric and curry powder, tomato extracts, and the vitamin E discovered within nuts and seeds do little to inhibit pro-growth signaling of prostate cancer cells—less than 10%.

But all three collectively suppresses increase signaling like 70%.

The entire is more than the sum of its elements.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty- sufferers with localized prostate [cancer]” had been given three-quarters of a cup of canned tomato sauce each day “for 3 weeks…earlier than their scheduled radical prostatectomy.” In their bloodstream, PSA stages dropped “via 17.5%.” PSA, prostate-precise antigen, is a protein produced via prostate gland cells, and multiplied blood degrees are mechanically used “to reveal the success of [cancer] treatment.

It turned into unexpected to locate that,” in just three weeks, a “tomato sauce-based totally nutritional intervention” ought to lower PSA concentrations within men with prostate most cancers. Also, unfastened radical damage of the DNA in their white blood cells dropped via 21%.

Imagine how antioxidant-negative their food plan should were beforehand, if less than a cup of tomato sauce a day may want to reduce DNA harm by means of more than a fifth.

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Okay, but what did they discover in their prostates? “[H]uman prostate tissue [is thought to] be particularly vulnerable to oxidative DNA damage through free radicals, which are thought to play a crucial position in all levels of [cancer formation].” This may be for some of reasons, including “fewer DNA repair enzymes.” Well, the researchers had tissue samples taken earlier than the tomato sauce from biopsies, and tissue samples after the 3 weeks of tomato sauce from the surgical procedure, and resected tissues from tomato sauce-supplemented sufferers had 28% less loose radical damage than predicted.

Here’s the DNA harm within the prostate before the tomato sauce, and here’s after.

Just 20 days of sauce. And, what’s thrilling is that “[t]here become no affiliation among” the level of lycopene within the prostate and the protecting consequences.

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Tomatoes include a whole bunch of things, a number of which may be even more powerful than lycopene.

Regardless, in comparison to the lycopene supplements by myself, “the entire-food intervention” seemed to help. To see if lycopene performed any position at all, one might have to check a lycopene-free tomato—within other words, a yellow tomato.

So, what in case you compared pink tomatoes to yellow tomatoes, that have all the non-lycopene tomato compounds, to immediately lycopene in a tablet?

So, they fed people crimson tomato paste, yellow tomato paste, lycopene capsules, or placebo tablets, after which dripped their blood on prostate cancer cells developing within a petri dish.

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Compared to the ones no longer eating some thing, the purple tomato serum, the blood from individuals who ate red tomato paste, extensively reduced the prostate cancer cell’s expression of a boom-promoting gene known as cyclin D1.

This downregulation of the gene with the aid of the purple tomato intake “may additionally make a contribution to lower prostate cancer hazard with the aid of proscribing cell proliferation.” The red tomato appeared to work higher than the yellow;

so, maybe the lycopene helped, however now not in tablet form. “[T]his gene became no longer regulated with the aid of [the lycopene-pill serum],” indicating that perhaps it’s something else.

And, lycopene alone drastically upregulated “procarcinogenic genes.

Do Topical Antioxidants Work