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But, lycopene in supplement shape doesn’t look like effective at decrease doses, both.

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“There is a sturdy [protective] correlation among the consumption of [actual whole] fruit[s] and vegetables and the incidence of positive cancers.” But when we complement with best a single compound remoted within tablet form, we may also dissatisfied the healthful natural stability of antioxidants. It does seem to be quite the human hubris to assume we can reproduce “the useful outcomes of consuming whole end result and veggies” through giving supplements of a single phytochemical, which could commonly engage with hundreds of different compounds within “the natural matrix” Mother Nature intended.

In addition to lycopene, other carotenoids in tomatoes encompass beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of that are acknowledged “to build up in human prostate tissue.” And, “there are also numerous non–carotenoid compounds in tomatoes that [may] have [anti-cancer] interest”—no longer to mention all of the compounds we've yet to even symbolize.

But, it’s no longer approximately locating the one magic bullet: “The anti-cancer results of carotenoids and different phytonutrients may additionally live within [their] mixed activity.” For instance, at the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene located in most people who eat regular amounts of tomatoes, there’s little or no impact on cancer mobile boom within vitro, used one at a time.

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But combine all of them together, and a non-effective dose plus a non-powerful dose will become powerful one way or the other, substantially suppressing prostate cancer cell boom.

And, the same synergy can be visible across meals. Curcumin, the yellow pigment in turmeric and curry powder, tomato extracts, and the vitamin E determined within nuts and seeds do little to inhibit seasoned-increase signaling of prostate most cancers cells—less than 10%.

But all three collectively suppresses growth signaling like 70%.

The complete is greater than the sum of its components.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty- sufferers with localized prostate [cancer]” were given three-quarters of a cup of canned tomato sauce each day “for three weeks…before their scheduled radical prostatectomy.” In their bloodstream, PSA degrees dropped “through 17.5%.” PSA, prostate-specific antigen, is a protein produced via prostate gland cells, and expanded blood degrees are robotically used “to display the success of [cancer] remedy.

It was surprising to discover that,” in just three weeks, a “tomato sauce-based dietary intervention” should lower PSA concentrations within men with prostate cancer. Also, loose radical damage of the DNA in their white blood cells dropped by 21%.

Imagine how antioxidant-bad their weight-reduction plan ought to had been ahead, if less than a cup of tomato sauce an afternoon ought to reduce DNA harm by more than a 5th.

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Okay, however what did they discover in their prostates? “[H]uman prostate tissue [is thought to] be especially liable to oxidative DNA damage by means of unfastened radicals, which might be concept to play a essential role in all stages of [cancer formation].” This can be for some of motives, along with “fewer DNA restore enzymes.” Well, the researchers had tissue samples taken before the tomato sauce from biopsies, and tissue samples after the 3 weeks of tomato sauce from the surgical procedure, and resected tissues from tomato sauce-supplemented sufferers had 28% much less free radical damage than expected.

Here’s the DNA harm inside the prostate earlier than the tomato sauce, and right here’s after.

Just 20 days of sauce. And, what’s thrilling is that “[t]right here was no association among” the level of lycopene in the prostate and the protective consequences.

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Tomatoes comprise an entire bunch of things, some of which can be even greater powerful than lycopene.

Regardless, in evaluation to the lycopene supplements by myself, “the complete-meals intervention” appeared to help. To see if lycopene performed any role at all, one might have to test a lycopene-loose tomato—in different words, a yellow tomato.

So, what if you as compared purple tomatoes to yellow tomatoes, which have all of the non-lycopene tomato compounds, to instantly lycopene in a pill?

So, they fed people red tomato paste, yellow tomato paste, lycopene drugs, or placebo pills, after which dripped their blood on prostate most cancers cells developing within a petri dish.

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Compared to those no longer ingesting some thing, the crimson tomato serum, the blood from people who ate purple tomato paste, notably reduced the prostate cancer cell’s expression of a growth-selling gene known as cyclin D1.

This downregulation of the gene by way of the crimson tomato intake “may additionally make contributions to lower prostate most cancers threat by restricting cell proliferation.” The crimson tomato appeared to paintings higher than the yellow;

so, maybe the lycopene helped, but now not within tablet shape. “[T]his gene changed into no longer regulated with the aid of [the lycopene-pill serum],” indicating that perhaps it’s something else.

And, lycopene by myself drastically upregulated “procarcinogenic genes.

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