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But, lycopene within complement form doesn’t appear like powerful at lower doses, both.

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“There is a strong [protective] correlation between the consumption of [actual whole] fruit[s] and greens and the occurrence of sure cancers.” But whilst we supplement with handiest a unmarried compound remoted within pill form, we may additionally upset the healthy herbal stability of antioxidants. It does appear to be quite the human hubris to suppose we can reproduce “the useful consequences of consuming complete end result and vegetables” by means of giving dietary supplements of a single phytochemical, which might usually have interaction with heaps of different compounds within “the natural matrix” Mother Nature supposed.

In addition to lycopene, other carotenoids in tomatoes encompass beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of which are regarded “to accumulate in human prostate tissue.” And, “there also are severa non–carotenoid compounds within tomatoes that [may] have [anti-cancer] hobby”—no longer to mention all the compounds we've got but to even characterize.

But, it’s no longer about finding the only magic bullet: “The anti-cancer outcomes of carotenoids and different phytonutrients may additionally live within [their] blended activity.” For instance, at the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene determined within most people who eat normal quantities of tomatoes, there’s very little impact on cancer mobile increase within vitro, used one by one.

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But combine them all collectively, and a non-effective dose plus a non-powerful dose will become powerful one way or the other, significantly suppressing prostate most cancers cell growth.

And, the identical synergy may be seen across foods. Curcumin, the yellow pigment in turmeric and curry powder, tomato extracts, and the nutrition E observed within nuts and seeds do little to inhibit seasoned-increase signaling of prostate cancer cells—less than 10%.

But all three collectively suppresses increase signaling like 70%.

The whole is more than the sum of its parts.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty-two sufferers with localized prostate [cancer]” had been given three-quarters of a cup of canned tomato sauce each day “for 3 weeks…earlier than their scheduled radical prostatectomy.” In their bloodstream, PSA degrees dropped “with the aid of 17.5%.” PSA, prostate-precise antigen, is a protein produced through prostate gland cells, and multiplied blood ranges are routinely used “to reveal the achievement of [cancer] treatment.

It became unexpected to locate that,” in only three weeks, a “tomato sauce-primarily based nutritional intervention” ought to decrease PSA concentrations in men with prostate most cancers. Also, unfastened radical damage of the DNA in their white blood cells dropped by way of 21%.

Imagine how antioxidant-poor their weight-reduction plan need to had been beforehand, if less than a cup of tomato sauce an afternoon may want to reduce DNA damage via greater than a 5th.

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Okay, however what did they locate of their prostates? “[H]uman prostate tissue [is thought to] be in particular vulnerable to oxidative DNA damage via loose radicals, which are thought to play a vital function in all degrees of [cancer formation].” This can be for some of motives, which includes “fewer DNA restore enzymes.” Well, the researchers had tissue samples taken earlier than the tomato sauce from biopsies, and tissue samples after the 3 weeks of tomato sauce from the surgical treatment, and resected tissues from tomato sauce-supplemented patients had 28% much less unfastened radical harm than anticipated.

Here’s the DNA harm within the prostate earlier than the tomato sauce, and here’s after.

Just 20 days of sauce. And, what’s interesting is that “[t]here became no affiliation between” the extent of lycopene inside the prostate and the protecting results.

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Tomatoes incorporate an entire bunch of factors, some of which may be even greater effective than lycopene.

Regardless, in assessment to the lycopene supplements on my own, “the complete-food intervention” seemed to help. To see if lycopene performed any role in any respect, one would have to test a lycopene-free tomato—within other words, a yellow tomato.

So, what if you in comparison crimson tomatoes to yellow tomatoes, that have all the non-lycopene tomato compounds, to straight lycopene in a tablet?

So, they fed humans crimson tomato paste, yellow tomato paste, lycopene pills, or placebo capsules, and then dripped their blood on prostate most cancers cells developing within a petri dish.

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Compared to the ones not consuming whatever, the red tomato serum, the blood from individuals who ate crimson tomato paste, appreciably reduced the prostate cancer cell’s expression of a growth-promoting gene called cyclin D1.

This downregulation of the gene by means of the red tomato intake “may also contribute to decrease prostate cancer risk by proscribing cell proliferation.” The red tomato seemed to paintings higher than the yellow;

so, perhaps the lycopene helped, however now not in pill shape. “[T]his gene became not regulated by using [the lycopene-pill serum],” indicating that perhaps it’s some thing else.

And, lycopene on my own extensively upregulated “procarcinogenic genes.

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