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First of all, do these bovine casomorphins form in the human digestive tract when we drink milk?

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Researchers decided to stick tubes down into human beings’s intestines to discover. And indeed, “[c]onsiderable amounts of…casomorphin…had been observed.” Okay, but do they get absorbed into the bloodstream?

Yes, reputedly so.

But, this research become on infants, who certainly have leakier guts. Do completely intact casein-protein fragments make it into the bloodstream after infancy?

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Yes, even into adulthood, elevating levels in the blood for as a minimum eight hours after intake.

And, people with autism may have an particularly leaky intestine—at significantly better danger for abnormally high intestinal permeability, which may additionally give an explanation for why the large majority of autistic youngsters may additionally have antibodies of their blood to wheat and dairy proteins, as compared to a small minority of everyday youngsters. And, based on hypersensitive reaction stories, despite the fact that an little one is precisely breastfed, they may still be exposed to bits of bovine milk proteins if the mother beverages milk, because the bovine protein fragments can get into her blood, then her breast, then into her infant’s body.

But, does it get into the infant’s mind?

Yeah, people with autism are more likely to suffer from leaky gut, however the so-known as “opioid extra concept” relies upon on casomorphins no longer handiest stepping into the bloodstream, but up into the critical frightened machine, the mind.

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And, there’s some thing called the blood-brain barrier that helps cordon off the mind.

When you examine the mind tissues of those with autism, their blood-mind barrier appears leakier, too.

And certainly, evidence for the presence of casomorphins in the brains of toddlers has since “been showed”—which, once more, just makes experience. That’s the complete presumed factor of casomorphin opioids—to have an effect on the brains of babies, in order that they crave the milk, cry out for the milk, strengthening the mother-infant bond, the cow-calf bond.

That’s what’s speculated to happen;

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it’s ordinary, natural. Okay, then, why are casomorphins associated with sickness?

Well, that is ordinary and natural.

This? Not a lot.

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Human infants with evidence of better baseline ranges of bovine casomorphins in their blood appear much more likely to be tormented by psychomotor delay, that is a measure of muscle, language, and intellectual function improvement.

But the opposite turned into observed for human little one exposure to human casomorphins—that means human casomorphins seemed to be beneficial within people. See, just like bovine casomorphin levels inside the infant’s blood appear to rise after feeding cow’s milk components, human casomorphin levels upward thrust in the infant after breastfeeding, and that’s what’s imagined to happen.

“The finest [baseline human casomorphins] was found out in breastfed babies with normal psychomotor improvement and muscle tone.

In contrast, accelerated [baseline bovine casomorphins] observed in [cow’s milk-]components-fed toddlers [was associated with] put off[ed] psychomotor development” and stiffened, extra inflexible, muscle tone.

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“The explanation of [the] contrary results of human [versus] bovine [casomorphins] on toddler… development…in all likelihood [has to do with] species-specificity.” Cow’s milk is ideal for calves;

breast milk is ideal for toddlers.

“Indeed, the shape of bovine and human [casein is dramatically different],” and the bovine and human casomorphins themselves are exceptional molecules, differing through  amino acids, which results in substantially distinctive potencies. Compared to human casomorphin, bovine casomorphin “is exceptionally potent and [more] similar to morphine in its results.” A -amino acid difference doesn’t look like loads, but casomorphins are best seven amino acids lengthy!

This 30% or so distinction “probably defines [the] difference in their biological properties.

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Both human and bovine [casomorphins]…interact with opioid and serotonin receptors, which might be acknowledged to be of super significance for [brain] maturation.” But cow casomorphin binds tighter to these receptors and, so, has greater of an effect. This can, therefore, assist explain now not simplest why breast is fine, but the psychomotor postpone linked with higher bovine casomorphin ranges in the blood supports this concept that cow casomorphins can also play a position in a disorder including autism.

This is why bovine casomorphins had been known as “the devil in the milk.” But, are they formed from all cow’s milk?

What about so-referred to as “A2” milk? The “A2 [milk] Corporation” factors accessible are exceptional “variations” of casein.

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Some cows deliver milk with a form of casein dubbed A1, and different cows produce milk with A2 casein, which differs from A1 casein “by using a single amino acid”—however strategically located such that A1 casein breaks down into casomorphin, which acts like morphine, “and is implicated in digestive, immune, and mind development modifications.” But, supposedly, A2 milk does now not.

Put A1 milk within a test tube with a few digestive enzymes, and the A1 casein breaks down into casomorphin. But, due to that amino acid difference, the A2 casein breaks down at a distinctive spot.

And so, no casomorphin is formed.

But, this was using digestive enzymes from pigs, or cows, that are simply less expensive and less complicated to buy for laboratory experiments.

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But human digestive juices are specific.

And so, what occurs in a pig’s belly or cow stomachs might not always be what occurs inside the human digestive tract.

But, the A1 as opposed to A2 breakdown experiment had by no means been finished with human enzymes earlier than, till…now. Human belly and intestinal juices had been received, and the devil was within both.

The opioid casomorphin changed into comprised of both A1 and A2 milk.