Gm Diet Day 1

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But, lycopene in complement form doesn’t look like powerful at decrease doses, both.

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“There is a strong [protective] correlation between the consumption of [actual whole] fruit[s] and veggies and the prevalence of sure cancers.” But while we supplement with handiest a unmarried compound remoted within tablet form, we may additionally dissatisfied the healthy natural stability of antioxidants. It does seem to be pretty the human hubris to assume we are able to reproduce “the useful results of ingesting complete culmination and greens” with the aid of giving supplements of a single phytochemical, which would typically engage with thousands of different compounds within “the herbal matrix” Mother Nature meant.

In addition to lycopene, other carotenoids within tomatoes consist of beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of which can be regarded “to accumulate within human prostate tissue.” And, “there also are severa non–carotenoid compounds within tomatoes that [may] have [anti-cancer] activity”—now not to say all of the compounds we have but to even signify.

But, it’s not about finding the only magic bullet: “The anti-cancer outcomes of carotenoids and different phytonutrients may additionally reside in [their] blended pastime.” For example, on the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene discovered within the general public who eat everyday quantities of tomatoes, there’s little or no impact on cancer cellular boom within vitro, used one after the other.

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But integrate all of them together, and a non-powerful dose plus a non-effective dose turns into powerful by some means, substantially suppressing prostate cancer cell boom.

And, the identical synergy can be seen across foods. Curcumin, the yellow pigment in turmeric and curry powder, tomato extracts, and the vitamin E found in nuts and seeds do little to inhibit pro-increase signaling of prostate most cancers cells—much less than 10%.

But all three together suppresses increase signaling like 70%.

The whole is more than the sum of its components.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty-two sufferers with localized prostate [cancer]” were given three-quarters of a cup of canned tomato sauce each day “for three weeks…before their scheduled radical prostatectomy.” In their bloodstream, PSA stages dropped “through 17.5%.” PSA, prostate-unique antigen, is a protein produced through prostate gland cells, and increased blood degrees are routinely used “to display the fulfillment of [cancer] treatment.

It became sudden to locate that,” in just three weeks, a “tomato sauce-primarily based dietary intervention” should lower PSA concentrations in men with prostate cancer. Also, loose radical harm of the DNA of their white blood cells dropped by means of 21%.

Imagine how antioxidant-bad their weight-reduction plan need to were beforehand, if much less than a cup of tomato sauce a day should reduce DNA harm through greater than a fifth.

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Okay, however what did they discover of their prostates? “[H]uman prostate tissue [is thought to] be particularly vulnerable to oxidative DNA harm by way of free radicals, which can be concept to play a essential function within all degrees of [cancer formation].” This can be for some of motives, along with “fewer DNA restore enzymes.” Well, the researchers had tissue samples taken earlier than the tomato sauce from biopsies, and tissue samples after the 3 weeks of tomato sauce from the surgical treatment, and resected tissues from tomato sauce-supplemented sufferers had 28% less unfastened radical harm than anticipated.

Here’s the DNA damage within the prostate before the tomato sauce, and right here’s after.

Just 20 days of sauce. And, what’s exciting is that “[t]here turned into no association among” the extent of lycopene in the prostate and the protecting outcomes.

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Tomatoes include an entire bunch of things, some of which may be even greater powerful than lycopene.

Regardless, within comparison to the lycopene supplements alone, “the complete-meals intervention” regarded to help. To see if lycopene played any position in any respect, one might have to test a lycopene-loose tomato—in other words, a yellow tomato.

So, what in case you as compared purple tomatoes to yellow tomatoes, that have all of the non-lycopene tomato compounds, to directly lycopene in a pill?

So, they fed humans purple tomato paste, yellow tomato paste, lycopene drugs, or placebo drugs, and then dripped their blood on prostate most cancers cells developing in a petri dish.

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Compared to those no longer ingesting some thing, the pink tomato serum, the blood from people who ate red tomato paste, considerably decreased the prostate most cancers mobile’s expression of a boom-selling gene called cyclin D1.

This downregulation of the gene by way of the purple tomato consumption “can also make contributions to decrease prostate cancer danger by means of limiting cellular proliferation.” The pink tomato seemed to work higher than the yellow;

so, maybe the lycopene helped, however not in pill form. “[T]his gene changed into not regulated through [the lycopene-pill serum],” indicating that perhaps it’s some thing else.

And, lycopene on my own considerably upregulated “procarcinogenic genes.