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But, lycopene in complement form doesn’t appear like effective at lower doses, either.

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“There is a strong [protective] correlation among the consumption of [actual whole] fruit[s] and vegetables and the prevalence of sure cancers.” But whilst we supplement with simplest a single compound remoted within pill form, we might also dissatisfied the healthy herbal balance of antioxidants. It does seem to be pretty the human hubris to suppose we will reproduce “the useful consequences of ingesting entire fruits and greens” through giving supplements of a single phytochemical, which could commonly have interaction with thousands of different compounds within “the natural matrix” Mother Nature supposed.

In addition to lycopene, other carotenoids in tomatoes consist of beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of which are recognized “to accumulate in human prostate tissue.” And, “there also are severa non–carotenoid compounds within tomatoes that [may] have [anti-cancer] interest”—not to say all the compounds we've yet to even signify.

But, it’s no longer about locating the one magic bullet: “The anti-most cancers effects of carotenoids and other phytonutrients may additionally live within [their] blended hobby.” For instance, on the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene located in most people who devour ordinary quantities of tomatoes, there’s little or no impact on cancer cell growth in vitro, used separately.

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But integrate all of them collectively, and a non-powerful dose plus a non-powerful dose turns into powerful by some means, appreciably suppressing prostate most cancers cellular increase.

And, the same synergy can be seen throughout ingredients. Curcumin, the yellow pigment within turmeric and curry powder, tomato extracts, and the diet E located in nuts and seeds do little to inhibit pro-boom signaling of prostate most cancers cells—less than 10%.

But all three collectively suppresses boom signaling like 70%.

The complete is more than the sum of its elements.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty- patients with localized prostate [cancer]” had been given three-quarters of a cup of canned tomato sauce each day “for 3 weeks…before their scheduled radical prostatectomy.” In their bloodstream, PSA ranges dropped “by way of 17.5%.” PSA, prostate-unique antigen, is a protein produced via prostate gland cells, and expanded blood tiers are mechanically used “to display the fulfillment of [cancer] treatment.

It was unexpected to locate that,” in just three weeks, a “tomato sauce-based nutritional intervention” may want to lower PSA concentrations within guys with prostate most cancers. Also, unfastened radical harm of the DNA of their white blood cells dropped by 21%.

Imagine how antioxidant-negative their weight loss program have to were ahead, if much less than a cup of tomato sauce a day may want to lessen DNA damage via greater than a 5th.

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Okay, however what did they find of their prostates? “[H]uman prostate tissue [is thought to] be specially susceptible to oxidative DNA damage by means of unfastened radicals, which are idea to play a important role within all tiers of [cancer formation].” This may be for a number of motives, which include “fewer DNA restore enzymes.” Well, the researchers had tissue samples taken earlier than the tomato sauce from biopsies, and tissue samples after the three weeks of tomato sauce from the surgical treatment, and resected tissues from tomato sauce-supplemented sufferers had 28% less unfastened radical damage than predicted.

Here’s the DNA damage inside the prostate before the tomato sauce, and right here’s after.

Just 20 days of sauce. And, what’s interesting is that “[t]right here turned into no affiliation among” the extent of lycopene within the prostate and the protective consequences.

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Tomatoes comprise an entire bunch of things, some of which can be even extra effective than lycopene.

Regardless, in assessment to the lycopene dietary supplements alone, “the whole-food intervention” appeared to help. To see if lycopene performed any function at all, one could have to check a lycopene-free tomato—in different words, a yellow tomato.

So, what if you compared red tomatoes to yellow tomatoes, which have all the non-lycopene tomato compounds, to immediately lycopene within a tablet?

So, they fed people red tomato paste, yellow tomato paste, lycopene pills, or placebo tablets, and then dripped their blood on prostate most cancers cells growing within a petri dish.

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Compared to the ones not eating anything, the red tomato serum, the blood from folks that ate red tomato paste, extensively decreased the prostate cancer mobile’s expression of a boom-promoting gene referred to as cyclin D1.

This downregulation of the gene by using the pink tomato intake “can also make a contribution to lower prostate cancer threat by using limiting mobile proliferation.” The crimson tomato appeared to work better than the yellow;

so, maybe the lycopene helped, however not in pill form. “[T]his gene became no longer regulated with the aid of [the lycopene-pill serum],” indicating that perhaps it’s some thing else.

And, lycopene by myself notably upregulated “procarcinogenic genes.

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