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They were essentially denied, with the FDA pronouncing that the proof became “very restrained and initial,” and not using a endorsement allowed for ketchup or supplements.

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By that point, in addition populace studies had cast doubt on the lycopene idea. Consumers of excessive dietary intakes of lycopene didn’t appear to have decrease cancer rates, in any case.

But, who has high dietary intakes of lycopene?

Those that devour the most pizza; so, maybe it’s no surprise there are combined outcomes.

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What we want is to position lycopene to the take a look at.

It started with a case study. A 62-12 months antique man with terminal prostate most cancers;

failed surgical procedure, failed chemotherapy, metastases all over, unfold to the bone.

And so, he became sent to hospice to die.

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So, he took it upon himself to initiate “phytotherapy”—plant-based totally therapy, taking the quantity of lycopene found within 1 / 4-cup of tomato sauce, or a tablespoon of tomato paste every day.

His PSA, a degree of tumor bulk, commenced out at 365, dropped to 140 the following month, after which down to 8.

His metastases started disappearing, and, as of his remaining comply with-up, seemed to be residing luckily ever after. But, when given in higher-dose tablet shape, it didn’t seem to work.

A 2013 review of all such lycopene complement trials “failed to aid [the initial] optimism.” In reality, they have been just satisfied that the lycopene pills didn’t become inflicting greater cancer, like beta-carotene drugs did.

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But, then came 2014. Researchers in Italy have been giving the largest doses they might of lycopene, selenium, and remoted inexperienced tea compounds to guys with precancerous prostate lesions, hoping they could prevent full-blown cancer.

But, within 2014, the accelerated consequences of a comparable trial were posted, wherein selenium and vitamin E supplements ended in extra cancer.

Yikes! So, these researchers stopped their trial, and broke the code to unblind the effects, And certainly, those taking excessive doses of lycopene, green tea catechins, and selenium regarded to get more most cancers than people who just got sugar pills.

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“The capability implications are dramatic,” stated the lead researcher, “given the contemporary huge international use of such compounds as alleged preventive vitamins in prostate and other cancers.” What went incorrect?

Well, after the beta-carotene tablet debacle, researchers measured mobile harm at distinct natural and unnatural doses of beta-carotene. At nutritional doses, beta-carotene suppressed cell harm, however at higher, supplemental doses, it now not handiest appeared to stop working, but precipitated greater damage.

And, the equal with lycopene.

“Both lycopene and [beta]-carotene afforded protection in opposition to DNA harm” at the types of levels one may see in humans consuming lots of tomatoes or sweet potatoes—”tiers…comparable with the ones visible within the [blood] of people who devour a carotenoid-rich wholesome food plan.” However, on the form of blood concentrations that one would possibly get taking drugs, “the capacity to guard the cells against such [free radical] damage was swiftly misplaced, and, certainly, the presence of [high levels of beta-carotene and lycopene] may also virtually serve to increase the extent of DNA damage.” So, no surprise excessive-dose lycopene tablets didn’t paintings.

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“Phytochemicals [may be] guardians of our health,” however “[t]he protection of consuming focused extracts…is unknown.” The defensive advantages of a phytochemical-rich food regimen is quality acquired [through whole plant foods].” The food enterprise has special thoughts, even though.