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But, lycopene in complement shape doesn’t look like effective at decrease doses, both.

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“There is a strong [protective] correlation between the consumption of [actual whole] fruit[s] and vegetables and the occurrence of certain cancers.” But whilst we supplement with most effective a unmarried compound remoted in pill form, we may additionally upset the healthful natural balance of antioxidants. It does appear to be pretty the human hubris to suppose we can reproduce “the beneficial consequences of eating whole culmination and greens” by using giving supplements of a unmarried phytochemical, which might generally interact with lots of different compounds in “the herbal matrix” Mother Nature intended.

In addition to lycopene, different carotenoids in tomatoes consist of beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of which might be acknowledged “to accumulate in human prostate tissue.” And, “there also are numerous non–carotenoid compounds in tomatoes that [may] have [anti-cancer] hobby”—now not to say all the compounds we've but to even signify.

But, it’s no longer approximately locating the one magic bullet: “The anti-most cancers effects of carotenoids and other phytonutrients might also live within [their] blended pastime.” For instance, on the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene located in the majority who consume regular quantities of tomatoes, there’s very little effect on most cancers cellular boom in vitro, used one at a time.

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But combine all of them together, and a non-effective dose plus a non-powerful dose becomes powerful in some way, appreciably suppressing prostate most cancers cell boom.

And, the same synergy may be seen throughout ingredients. Curcumin, the yellow pigment within turmeric and curry powder, tomato extracts, and the vitamin E determined within nuts and seeds do little to inhibit seasoned-growth signaling of prostate most cancers cells—less than 10%.

But all three collectively suppresses boom signaling like 70%.

The entire is more than the sum of its elements.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty- sufferers with localized prostate [cancer]” have been given three-quarters of a cup of canned tomato sauce each day “for three weeks…earlier than their scheduled radical prostatectomy.” In their bloodstream, PSA degrees dropped “with the aid of 17.5%.” PSA, prostate-unique antigen, is a protein produced with the aid of prostate gland cells, and increased blood ranges are robotically used “to display the fulfillment of [cancer] treatment.

It become unexpected to find that,” in just three weeks, a “tomato sauce-based dietary intervention” could decrease PSA concentrations within men with prostate most cancers. Also, loose radical damage of the DNA of their white blood cells dropped through 21%.

Imagine how antioxidant-negative their weight loss plan have to had been beforehand, if less than a cup of tomato sauce a day should reduce DNA harm by way of more than a 5th.

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Okay, but what did they find in their prostates? “[H]uman prostate tissue [is thought to] be especially vulnerable to oxidative DNA damage through free radicals, which are concept to play a important position within all degrees of [cancer formation].” This may be for a number of motives, including “fewer DNA restore enzymes.” Well, the researchers had tissue samples taken earlier than the tomato sauce from biopsies, and tissue samples after the three weeks of tomato sauce from the surgical treatment, and resected tissues from tomato sauce-supplemented sufferers had 28% less loose radical damage than predicted.

Here’s the DNA damage in the prostate earlier than the tomato sauce, and here’s after.

Just 20 days of sauce. And, what’s interesting is that “[t]here was no association between” the level of lycopene in the prostate and the protecting outcomes.

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Tomatoes incorporate a whole bunch of things, a number of which can be even extra effective than lycopene.

Regardless, in comparison to the lycopene supplements on my own, “the whole-food intervention” appeared to help. To see if lycopene played any function in any respect, one could have to test a lycopene-unfastened tomato—in other words, a yellow tomato.

So, what in case you as compared purple tomatoes to yellow tomatoes, which have all the non-lycopene tomato compounds, to directly lycopene within a pill?

So, they fed human beings crimson tomato paste, yellow tomato paste, lycopene capsules, or placebo drugs, and then dripped their blood on prostate most cancers cells developing within a petri dish.

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Compared to the ones no longer ingesting something, the pink tomato serum, the blood from individuals who ate red tomato paste, considerably decreased the prostate most cancers mobile’s expression of a boom-promoting gene called cyclin D1.

This downregulation of the gene by using the pink tomato consumption “may also make contributions to lower prostate most cancers danger by using restricting cell proliferation.” The pink tomato regarded to paintings higher than the yellow;

so, maybe the lycopene helped, but no longer within tablet shape. “[T]his gene become now not regulated through [the lycopene-pill serum],” indicating that maybe it’s something else.

And, lycopene alone drastically upregulated “procarcinogenic genes.

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