High Lycopene

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But, lycopene in complement form doesn’t look like effective at decrease doses, both.

High Lycopene Tomatoes

“There is a sturdy [protective] correlation among the intake of [actual whole] fruit[s] and greens and the prevalence of certain cancers.” But when we supplement with best a single compound remoted in tablet form, we might also disenchanted the wholesome natural balance of antioxidants. It does appear to be pretty the human hubris to assume we can reproduce “the beneficial consequences of ingesting complete end result and veggies” with the aid of giving dietary supplements of a unmarried phytochemical, which might normally engage with hundreds of other compounds within “the natural matrix” Mother Nature meant.

In addition to lycopene, other carotenoids in tomatoes include beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of which might be regarded “to build up in human prostate tissue.” And, “there are also numerous non–carotenoid compounds within tomatoes that [may] have [anti-cancer] interest”—no longer to mention all the compounds we've got yet to even signify.

But, it’s now not approximately finding the only magic bullet: “The anti-cancer outcomes of carotenoids and different phytonutrients may reside in [their] mixed pastime.” For instance, on the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene determined within most people who consume normal quantities of tomatoes, there’s little or no effect on cancer cell boom within vitro, used one at a time.

High Lycopene Diet

But integrate them all collectively, and a non-effective dose plus a non-effective dose will become effective someway, appreciably suppressing prostate most cancers cell increase.

And, the same synergy may be visible across ingredients. Curcumin, the yellow pigment in turmeric and curry powder, tomato extracts, and the vitamin E located in nuts and seeds do little to inhibit pro-increase signaling of prostate most cancers cells—less than 10%.

But all three together suppresses increase signaling like 70%.

The complete is extra than the sum of its elements.

High Lycopene Tomato Seeds

So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty-two patients with localized prostate [cancer]” were given three-quarters of a cup of canned tomato sauce every day “for 3 weeks…earlier than their scheduled radical prostatectomy.” In their bloodstream, PSA ranges dropped “by 17.5%.” PSA, prostate-unique antigen, is a protein produced with the aid of prostate gland cells, and extended blood degrees are routinely used “to screen the fulfillment of [cancer] remedy.

It changed into surprising to locate that,” in just three weeks, a “tomato sauce-based dietary intervention” may want to lower PSA concentrations within men with prostate cancer. Also, loose radical damage of the DNA in their white blood cells dropped via 21%.

Imagine how antioxidant-terrible their weight-reduction plan need to had been in advance, if less than a cup of tomato sauce an afternoon could lessen DNA harm by using extra than a 5th.

High Lycopene Tomato Paste

Okay, but what did they discover of their prostates? “[H]uman prostate tissue [is thought to] be in particular vulnerable to oxidative DNA harm by means of loose radicals, which can be thought to play a vital position in all degrees of [cancer formation].” This may be for a number of reasons, which include “fewer DNA repair enzymes.” Well, the researchers had tissue samples taken earlier than the tomato sauce from biopsies, and tissue samples after the 3 weeks of tomato sauce from the surgical treatment, and resected tissues from tomato sauce-supplemented sufferers had 28% less loose radical damage than predicted.

Here’s the DNA harm inside the prostate before the tomato sauce, and right here’s after.

Just 20 days of sauce. And, what’s interesting is that “[t]here was no association between” the extent of lycopene in the prostate and the protective outcomes.

High Lycopene Varieties

Tomatoes comprise an entire bunch of factors, a number of which can be even greater effective than lycopene.

Regardless, within assessment to the lycopene dietary supplements on my own, “the entire-food intervention” seemed to help. To see if lycopene performed any role at all, one would have to check a lycopene-loose tomato—in other words, a yellow tomato.

So, what if you as compared red tomatoes to yellow tomatoes, that have all the non-lycopene tomato compounds, to directly lycopene within a tablet?

So, they fed humans crimson tomato paste, yellow tomato paste, lycopene pills, or placebo tablets, and then dripped their blood on prostate most cancers cells growing in a petri dish.

Lycopene High Blood Pressure

Compared to those no longer eating anything, the crimson tomato serum, the blood from folks who ate red tomato paste, substantially decreased the prostate cancer cellular’s expression of a growth-selling gene known as cyclin D1.

This downregulation of the gene by the crimson tomato intake “may additionally make contributions to lower prostate most cancers danger with the aid of proscribing cellular proliferation.” The pink tomato regarded to work better than the yellow;

so, perhaps the lycopene helped, however no longer within pill shape. “[T]his gene changed into no longer regulated by [the lycopene-pill serum],” indicating that perhaps it’s something else.

And, lycopene on my own appreciably upregulated “procarcinogenic genes.

Lycopene High Dose