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But, lycopene in supplement shape doesn’t look like effective at lower doses, both.

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“There is a robust [protective] correlation among the consumption of [actual whole] fruit[s] and vegetables and the occurrence of positive cancers.” But while we supplement with best a unmarried compound isolated within tablet shape, we may also dissatisfied the wholesome herbal balance of antioxidants. It does appear to be quite the human hubris to think we are able to reproduce “the useful effects of consuming complete end result and greens” with the aid of giving dietary supplements of a single phytochemical, which might usually engage with hundreds of other compounds within “the herbal matrix” Mother Nature supposed.

In addition to lycopene, different carotenoids in tomatoes consist of beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of which might be recognized “to build up in human prostate tissue.” And, “there are also numerous non–carotenoid compounds in tomatoes that [may] have [anti-cancer] activity”—now not to say all the compounds we've but to even symbolize.

But, it’s not about locating the only magic bullet: “The anti-most cancers outcomes of carotenoids and different phytonutrients may reside within [their] mixed interest.” For instance, at the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene discovered within most of the people who consume normal amounts of tomatoes, there’s little or no effect on cancer cellular boom in vitro, used one after the other.

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But integrate them all collectively, and a non-powerful dose plus a non-effective dose turns into powerful in some way, significantly suppressing prostate cancer cellular growth.

And, the equal synergy may be visible throughout ingredients. Curcumin, the yellow pigment within turmeric and curry powder, tomato extracts, and the vitamin E determined within nuts and seeds do little to inhibit pro-growth signaling of prostate most cancers cells—much less than 10%.

But all three collectively suppresses growth signaling like 70%.

The whole is extra than the sum of its components.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty-two patients with localized prostate [cancer]” were given three-quarters of a cup of canned tomato sauce every day “for three weeks…earlier than their scheduled radical prostatectomy.” In their bloodstream, PSA degrees dropped “by way of 17.5%.” PSA, prostate-particular antigen, is a protein produced by way of prostate gland cells, and increased blood levels are mechanically used “to screen the achievement of [cancer] treatment.

It became unexpected to find that,” in just three weeks, a “tomato sauce-based totally dietary intervention” should decrease PSA concentrations in men with prostate most cancers. Also, unfastened radical harm of the DNA in their white blood cells dropped via 21%.

Imagine how antioxidant-negative their eating regimen have to were ahead, if much less than a cup of tomato sauce an afternoon could reduce DNA damage through greater than a 5th.

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Okay, but what did they locate in their prostates? “[H]uman prostate tissue [is thought to] be mainly vulnerable to oxidative DNA harm by means of unfastened radicals, which might be idea to play a important function in all degrees of [cancer formation].” This may be for some of motives, including “fewer DNA repair enzymes.” Well, the researchers had tissue samples taken earlier than the tomato sauce from biopsies, and tissue samples after the 3 weeks of tomato sauce from the surgical treatment, and resected tissues from tomato sauce-supplemented sufferers had 28% much less loose radical damage than predicted.

Here’s the DNA damage inside the prostate before the tomato sauce, and right here’s after.

Just 20 days of sauce. And, what’s thrilling is that “[t]here turned into no affiliation among” the level of lycopene inside the prostate and the protecting effects.

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Tomatoes contain an entire bunch of things, some of which may be even greater powerful than lycopene.

Regardless, in assessment to the lycopene dietary supplements by myself, “the entire-meals intervention” seemed to assist. To see if lycopene played any function in any respect, one would have to test a lycopene-loose tomato—in other words, a yellow tomato.

So, what if you compared pink tomatoes to yellow tomatoes, that have all of the non-lycopene tomato compounds, to instantly lycopene within a pill?

So, they fed humans purple tomato paste, yellow tomato paste, lycopene drugs, or placebo tablets, after which dripped their blood on prostate cancer cells growing within a petri dish.

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Compared to those no longer eating something, the red tomato serum, the blood from folks that ate pink tomato paste, extensively reduced the prostate cancer cell’s expression of a growth-selling gene referred to as cyclin D1.

This downregulation of the gene by way of the purple tomato intake “may additionally contribute to decrease prostate cancer threat by using restricting cellular proliferation.” The pink tomato appeared to work higher than the yellow;

so, maybe the lycopene helped, however not within tablet shape. “[T]his gene become no longer regulated by using [the lycopene-pill serum],” indicating that perhaps it’s some thing else.

And, lycopene on my own extensively upregulated “procarcinogenic genes.

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