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But, lycopene in complement form doesn’t look like powerful at lower doses, either.

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“There is a sturdy [protective] correlation among the intake of [actual whole] fruit[s] and vegetables and the incidence of certain cancers.” But while we supplement with best a unmarried compound remoted in tablet form, we can also disappointed the healthful natural stability of antioxidants. It does seem to be pretty the human hubris to suppose we will reproduce “the beneficial outcomes of ingesting entire fruits and greens” by means of giving supplements of a unmarried phytochemical, which could generally interact with thousands of different compounds in “the natural matrix” Mother Nature supposed.

In addition to lycopene, different carotenoids in tomatoes encompass beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of that are recognized “to accumulate in human prostate tissue.” And, “there are also numerous non–carotenoid compounds in tomatoes that [may] have [anti-cancer] hobby”—no longer to mention all of the compounds we have but to even characterize.

But, it’s now not about finding the only magic bullet: “The anti-cancer results of carotenoids and different phytonutrients can also reside within [their] blended interest.” For example, on the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene discovered within the majority who eat ordinary amounts of tomatoes, there’s little or no impact on most cancers cell growth within vitro, used separately.

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But combine them all collectively, and a non-powerful dose plus a non-effective dose becomes effective somehow, drastically suppressing prostate most cancers mobile growth.

And, the identical synergy may be seen across ingredients. Curcumin, the yellow pigment in turmeric and curry powder, tomato extracts, and the diet E discovered in nuts and seeds do little to inhibit seasoned-boom signaling of prostate most cancers cells—less than 10%.

But all three collectively suppresses growth signaling like 70%.

The entire is greater than the sum of its parts.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty- sufferers with localized prostate [cancer]” have been given three-quarters of a cup of canned tomato sauce each day “for 3 weeks…before their scheduled radical prostatectomy.” In their bloodstream, PSA tiers dropped “by 17.5%.” PSA, prostate-particular antigen, is a protein produced by way of prostate gland cells, and increased blood levels are robotically used “to reveal the fulfillment of [cancer] remedy.

It was surprising to locate that,” in just three weeks, a “tomato sauce-primarily based nutritional intervention” ought to decrease PSA concentrations within guys with prostate most cancers. Also, unfastened radical harm of the DNA of their white blood cells dropped via 21%.

Imagine how antioxidant-bad their weight-reduction plan need to were in advance, if much less than a cup of tomato sauce an afternoon ought to reduce DNA damage via extra than a fifth.

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Okay, but what did they find in their prostates? “[H]uman prostate tissue [is thought to] be in particular susceptible to oxidative DNA harm by using free radicals, which might be concept to play a critical function within all levels of [cancer formation].” This can be for a number of reasons, such as “fewer DNA repair enzymes.” Well, the researchers had tissue samples taken before the tomato sauce from biopsies, and tissue samples after the three weeks of tomato sauce from the surgical operation, and resected tissues from tomato sauce-supplemented patients had 28% much less loose radical damage than anticipated.

Here’s the DNA harm within the prostate earlier than the tomato sauce, and right here’s after.

Just 20 days of sauce. And, what’s thrilling is that “[t]right here changed into no association between” the level of lycopene inside the prostate and the protecting results.

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Tomatoes incorporate an entire bunch of things, a number of which can be even greater powerful than lycopene.

Regardless, in evaluation to the lycopene supplements on my own, “the entire-meals intervention” regarded to help. To see if lycopene played any function in any respect, one could have to check a lycopene-loose tomato—in other words, a yellow tomato.

So, what in case you compared purple tomatoes to yellow tomatoes, that have all the non-lycopene tomato compounds, to immediately lycopene within a tablet?

So, they fed people red tomato paste, yellow tomato paste, lycopene drugs, or placebo drugs, after which dripped their blood on prostate cancer cells developing in a petri dish.

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Compared to those now not eating some thing, the purple tomato serum, the blood from those who ate purple tomato paste, extensively reduced the prostate most cancers cellular’s expression of a boom-selling gene called cyclin D1.

This downregulation of the gene by the crimson tomato consumption “may additionally make contributions to decrease prostate cancer hazard via limiting cell proliferation.” The red tomato regarded to paintings better than the yellow;

so, perhaps the lycopene helped, but not within pill shape. “[T]his gene was not regulated by way of [the lycopene-pill serum],” indicating that perhaps it’s something else.

And, lycopene by myself notably upregulated “procarcinogenic genes.

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