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But, lycopene in complement form doesn’t appear like powerful at lower doses, either.

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“There is a robust [protective] correlation between the consumption of [actual whole] fruit[s] and veggies and the prevalence of positive cancers.” But while we complement with handiest a single compound isolated within tablet form, we may dissatisfied the wholesome natural stability of antioxidants. It does appear to be quite the human hubris to think we can reproduce “the beneficial effects of ingesting entire end result and vegetables” by way of giving supplements of a unmarried phytochemical, which could commonly interact with heaps of different compounds in “the natural matrix” Mother Nature supposed.

In addition to lycopene, other carotenoids within tomatoes encompass beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of which might be recognized “to accumulate in human prostate tissue.” And, “there are also numerous non–carotenoid compounds within tomatoes that [may] have [anti-cancer] activity”—no longer to mention all the compounds we've got yet to even represent.

But, it’s no longer approximately finding the only magic bullet: “The anti-most cancers consequences of carotenoids and different phytonutrients may reside in [their] blended interest.” For instance, at the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene determined in the general public who devour ordinary quantities of tomatoes, there’s very little effect on cancer cellular boom in vitro, used one at a time.

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But combine all of them collectively, and a non-effective dose plus a non-powerful dose becomes effective someway, notably suppressing prostate cancer mobile boom.

And, the equal synergy can be visible across meals. Curcumin, the yellow pigment within turmeric and curry powder, tomato extracts, and the diet E found in nuts and seeds do little to inhibit pro-increase signaling of prostate cancer cells—much less than 10%.

But all three collectively suppresses boom signaling like 70%.

The whole is greater than the sum of its parts.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty- patients with localized prostate [cancer]” have been given three-quarters of a cup of canned tomato sauce every day “for three weeks…before their scheduled radical prostatectomy.” In their bloodstream, PSA tiers dropped “by 17.5%.” PSA, prostate-specific antigen, is a protein produced by prostate gland cells, and expanded blood degrees are robotically used “to display the fulfillment of [cancer] remedy.

It become surprising to discover that,” in just three weeks, a “tomato sauce-based totally dietary intervention” ought to decrease PSA concentrations within men with prostate cancer. Also, unfastened radical damage of the DNA in their white blood cells dropped by 21%.

Imagine how antioxidant-negative their food plan ought to had been in advance, if less than a cup of tomato sauce an afternoon could lessen DNA damage by using greater than a 5th.

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Okay, but what did they find of their prostates? “[H]uman prostate tissue [is thought to] be specifically susceptible to oxidative DNA damage by free radicals, that are concept to play a important role within all ranges of [cancer formation].” This can be for some of reasons, which includes “fewer DNA repair enzymes.” Well, the researchers had tissue samples taken earlier than the tomato sauce from biopsies, and tissue samples after the 3 weeks of tomato sauce from the surgical operation, and resected tissues from tomato sauce-supplemented sufferers had 28% less unfastened radical damage than expected.

Here’s the DNA harm inside the prostate earlier than the tomato sauce, and right here’s after.

Just 20 days of sauce. And, what’s interesting is that “[t]right here became no affiliation between” the level of lycopene inside the prostate and the protecting effects.

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Tomatoes contain an entire bunch of things, some of which can be even greater powerful than lycopene.

Regardless, within assessment to the lycopene dietary supplements alone, “the complete-meals intervention” seemed to assist. To see if lycopene performed any function at all, one might have to test a lycopene-loose tomato—in different words, a yellow tomato.

So, what if you compared pink tomatoes to yellow tomatoes, which have all the non-lycopene tomato compounds, to straight lycopene within a tablet?

So, they fed humans red tomato paste, yellow tomato paste, lycopene drugs, or placebo pills, and then dripped their blood on prostate most cancers cells developing within a petri dish.

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Compared to those not consuming anything, the purple tomato serum, the blood from people who ate purple tomato paste, considerably decreased the prostate most cancers cell’s expression of a increase-selling gene called cyclin D1.

This downregulation of the gene by the crimson tomato consumption “may also make a contribution to lower prostate cancer hazard by using proscribing mobile proliferation.” The pink tomato regarded to work higher than the yellow;

so, maybe the lycopene helped, but not in pill form. “[T]his gene changed into no longer regulated by using [the lycopene-pill serum],” indicating that perhaps it’s some thing else.

And, lycopene on my own drastically upregulated “procarcinogenic genes.

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