Lycopene Antioxidant

Mark Velov Author: Mark Velov Time for reading: ~4 minutes Last Updated: August 08, 2022
Lycopene Antioxidant

Learn more information about lycopene antioxidant. In this article we'll discuss lycopene antioxidant.

But, lycopene in supplement form doesn’t seem like powerful at decrease doses, both.

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“There is a robust [protective] correlation between the intake of [actual whole] fruit[s] and vegetables and the incidence of certain cancers.” But while we supplement with handiest a single compound isolated in tablet shape, we might also disenchanted the healthy herbal balance of antioxidants. It does seem to be pretty the human hubris to suppose we are able to reproduce “the useful effects of ingesting entire culmination and vegetables” via giving supplements of a unmarried phytochemical, which could commonly have interaction with lots of different compounds within “the herbal matrix” Mother Nature meant.

In addition to lycopene, different carotenoids within tomatoes include beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of which can be acknowledged “to accumulate within human prostate tissue.” And, “there also are numerous non–carotenoid compounds in tomatoes that [may] have [anti-cancer] interest”—no longer to say all of the compounds we've but to even symbolize.

But, it’s not approximately finding the one magic bullet: “The anti-most cancers outcomes of carotenoids and other phytonutrients may additionally live within [their] combined hobby.” For instance, at the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene discovered within most of the people who consume normal quantities of tomatoes, there’s very little effect on most cancers mobile boom in vitro, used one by one.

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But combine them all together, and a non-effective dose plus a non-powerful dose will become powerful in some way, significantly suppressing prostate most cancers mobile boom.

And, the identical synergy may be seen across ingredients. Curcumin, the yellow pigment in turmeric and curry powder, tomato extracts, and the diet E located within nuts and seeds do little to inhibit pro-increase signaling of prostate cancer cells—much less than 10%.

But all three together suppresses increase signaling like 70%.

The complete is greater than the sum of its components.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty- sufferers with localized prostate [cancer]” had been given three-quarters of a cup of canned tomato sauce every day “for three weeks…earlier than their scheduled radical prostatectomy.” In their bloodstream, PSA tiers dropped “by 17.5%.” PSA, prostate-particular antigen, is a protein produced with the aid of prostate gland cells, and accelerated blood levels are robotically used “to reveal the achievement of [cancer] treatment.

It become surprising to find that,” in only three weeks, a “tomato sauce-based nutritional intervention” may want to decrease PSA concentrations in men with prostate cancer. Also, loose radical harm of the DNA in their white blood cells dropped via 21%.

Imagine how antioxidant-poor their eating regimen must were beforehand, if less than a cup of tomato sauce an afternoon could lessen DNA damage through extra than a fifth.

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Okay, however what did they locate in their prostates? “[H]uman prostate tissue [is thought to] be especially prone to oxidative DNA damage through loose radicals, which can be thought to play a critical position within all levels of [cancer formation].” This may be for a number of reasons, together with “fewer DNA repair enzymes.” Well, the researchers had tissue samples taken earlier than the tomato sauce from biopsies, and tissue samples after the three weeks of tomato sauce from the surgical treatment, and resected tissues from tomato sauce-supplemented patients had 28% less free radical harm than predicted.

Here’s the DNA damage in the prostate earlier than the tomato sauce, and here’s after.

Just 20 days of sauce. And, what’s exciting is that “[t]right here become no affiliation between” the extent of lycopene in the prostate and the protective consequences.

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Tomatoes comprise a whole bunch of factors, a number of which may be even more effective than lycopene.

Regardless, within contrast to the lycopene supplements on my own, “the whole-food intervention” seemed to help. To see if lycopene performed any function in any respect, one would have to test a lycopene-loose tomato—within other phrases, a yellow tomato.

So, what in case you compared purple tomatoes to yellow tomatoes, which have all of the non-lycopene tomato compounds, to straight lycopene within a pill?

So, they fed people crimson tomato paste, yellow tomato paste, lycopene drugs, or placebo pills, after which dripped their blood on prostate cancer cells developing in a petri dish.

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Compared to those now not consuming anything, the red tomato serum, the blood from those who ate crimson tomato paste, substantially reduced the prostate cancer cellular’s expression of a growth-promoting gene called cyclin D1.

This downregulation of the gene with the aid of the purple tomato consumption “may additionally make a contribution to decrease prostate cancer danger by limiting mobile proliferation.” The red tomato seemed to work higher than the yellow;

so, maybe the lycopene helped, but no longer in tablet form. “[T]his gene was now not regulated by way of [the lycopene-pill serum],” indicating that perhaps it’s something else.

And, lycopene alone notably upregulated “procarcinogenic genes.

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