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But, lycopene in supplement form doesn’t appear like powerful at decrease doses, either.

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“There is a strong [protective] correlation between the intake of [actual whole] fruit[s] and vegetables and the prevalence of positive cancers.” But whilst we supplement with most effective a unmarried compound isolated in tablet shape, we may additionally disappointed the wholesome herbal balance of antioxidants. It does seem to be quite the human hubris to assume we are able to reproduce “the beneficial effects of ingesting whole culmination and veggies” by using giving supplements of a unmarried phytochemical, which might typically interact with heaps of other compounds in “the herbal matrix” Mother Nature supposed.

In addition to lycopene, different carotenoids in tomatoes include beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of which might be known “to accumulate in human prostate tissue.” And, “there are also numerous non–carotenoid compounds in tomatoes that [may] have [anti-cancer] activity”—now not to say all the compounds we've but to even characterize.

But, it’s not about finding the one magic bullet: “The anti-most cancers effects of carotenoids and other phytonutrients may additionally are living in [their] combined pastime.” For instance, on the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene found within most of the people who consume regular amounts of tomatoes, there’s very little effect on cancer cell growth in vitro, used separately.

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But combine them all collectively, and a non-powerful dose plus a non-effective dose will become powerful someway, drastically suppressing prostate most cancers mobile boom.

And, the equal synergy may be visible across ingredients. Curcumin, the yellow pigment in turmeric and curry powder, tomato extracts, and the diet E found within nuts and seeds do little to inhibit seasoned-boom signaling of prostate most cancers cells—much less than 10%.

But all three together suppresses growth signaling like 70%.

The whole is greater than the sum of its parts.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty- sufferers with localized prostate [cancer]” had been given three-quarters of a cup of canned tomato sauce each day “for 3 weeks…before their scheduled radical prostatectomy.” In their bloodstream, PSA ranges dropped “through 17.5%.” PSA, prostate-precise antigen, is a protein produced by prostate gland cells, and improved blood tiers are mechanically used “to reveal the fulfillment of [cancer] treatment.

It changed into sudden to discover that,” in just three weeks, a “tomato sauce-based totally dietary intervention” may want to lower PSA concentrations within guys with prostate cancer. Also, loose radical damage of the DNA of their white blood cells dropped by way of 21%.

Imagine how antioxidant-negative their weight loss plan need to were ahead, if less than a cup of tomato sauce a day should reduce DNA harm by greater than a fifth.

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Okay, however what did they discover in their prostates? “[H]uman prostate tissue [is thought to] be specially prone to oxidative DNA harm by loose radicals, which are thought to play a essential function in all ranges of [cancer formation].” This can be for some of motives, along with “fewer DNA repair enzymes.” Well, the researchers had tissue samples taken earlier than the tomato sauce from biopsies, and tissue samples after the three weeks of tomato sauce from the surgical procedure, and resected tissues from tomato sauce-supplemented patients had 28% much less unfastened radical damage than expected.

Here’s the DNA damage inside the prostate before the tomato sauce, and right here’s after.

Just 20 days of sauce. And, what’s thrilling is that “[t]right here was no affiliation among” the extent of lycopene in the prostate and the protecting consequences.

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Tomatoes include a whole bunch of things, some of which may be even greater effective than lycopene.

Regardless, in evaluation to the lycopene supplements on my own, “the complete-food intervention” appeared to assist. To see if lycopene played any function in any respect, one could have to check a lycopene-loose tomato—in different phrases, a yellow tomato.

So, what in case you compared purple tomatoes to yellow tomatoes, that have all the non-lycopene tomato compounds, to directly lycopene within a pill?

So, they fed people crimson tomato paste, yellow tomato paste, lycopene tablets, or placebo capsules, and then dripped their blood on prostate cancer cells growing within a petri dish.

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Compared to those now not ingesting something, the red tomato serum, the blood from folks who ate crimson tomato paste, extensively reduced the prostate cancer cellular’s expression of a boom-selling gene referred to as cyclin D1.

This downregulation of the gene with the aid of the pink tomato consumption “may additionally contribute to decrease prostate most cancers threat through limiting cell proliferation.” The red tomato seemed to work better than the yellow;

so, perhaps the lycopene helped, however no longer in tablet shape. “[T]his gene became no longer regulated by way of [the lycopene-pill serum],” indicating that perhaps it’s some thing else.

And, lycopene alone drastically upregulated “procarcinogenic genes.

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