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But, lycopene in complement form doesn’t look like effective at lower doses, either.

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“There is a robust [protective] correlation between the intake of [actual whole] fruit[s] and greens and the occurrence of positive cancers.” But when we supplement with simplest a unmarried compound isolated in tablet shape, we may also disappointed the wholesome natural stability of antioxidants. It does appear to be quite the human hubris to suppose we are able to reproduce “the useful consequences of ingesting whole end result and veggies” through giving supplements of a unmarried phytochemical, which would usually interact with thousands of other compounds in “the herbal matrix” Mother Nature intended.

In addition to lycopene, different carotenoids in tomatoes encompass beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of which might be recognised “to build up in human prostate tissue.” And, “there are also severa non–carotenoid compounds in tomatoes that [may] have [anti-cancer] activity”—not to mention all the compounds we've got but to even signify.

But, it’s not approximately locating the one magic bullet: “The anti-most cancers outcomes of carotenoids and other phytonutrients may additionally live within [their] blended pastime.” For example, on the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene discovered within the general public who consume ordinary quantities of tomatoes, there’s little or no effect on cancer mobile increase in vitro, used one by one.

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But combine all of them together, and a non-effective dose plus a non-effective dose turns into effective by hook or by crook, appreciably suppressing prostate cancer cell increase.

And, the equal synergy can be visible throughout meals. Curcumin, the yellow pigment in turmeric and curry powder, tomato extracts, and the nutrition E located within nuts and seeds do little to inhibit pro-boom signaling of prostate cancer cells—less than 10%.

But all three together suppresses increase signaling like 70%.

The whole is more than the sum of its components.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty- sufferers with localized prostate [cancer]” had been given three-quarters of a cup of canned tomato sauce every day “for three weeks…earlier than their scheduled radical prostatectomy.” In their bloodstream, PSA degrees dropped “by means of 17.5%.” PSA, prostate-precise antigen, is a protein produced by means of prostate gland cells, and increased blood ranges are automatically used “to display the success of [cancer] treatment.

It turned into surprising to discover that,” in just three weeks, a “tomato sauce-primarily based dietary intervention” should lower PSA concentrations within guys with prostate most cancers. Also, loose radical harm of the DNA of their white blood cells dropped by way of 21%.

Imagine how antioxidant-poor their weight loss program should had been in advance, if much less than a cup of tomato sauce a day could lessen DNA harm by using greater than a fifth.

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Okay, however what did they locate in their prostates? “[H]uman prostate tissue [is thought to] be specially prone to oxidative DNA harm by unfastened radicals, which might be concept to play a critical position in all stages of [cancer formation].” This can be for some of reasons, which includes “fewer DNA restore enzymes.” Well, the researchers had tissue samples taken earlier than the tomato sauce from biopsies, and tissue samples after the three weeks of tomato sauce from the surgery, and resected tissues from tomato sauce-supplemented sufferers had 28% less loose radical damage than expected.

Here’s the DNA damage in the prostate before the tomato sauce, and right here’s after.

Just 20 days of sauce. And, what’s interesting is that “[t]right here turned into no affiliation among” the level of lycopene within the prostate and the protecting effects.

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Tomatoes comprise a whole bunch of things, a number of which can be even more powerful than lycopene.

Regardless, within comparison to the lycopene supplements alone, “the whole-food intervention” seemed to help. To see if lycopene performed any function in any respect, one might have to check a lycopene-loose tomato—in other phrases, a yellow tomato.

So, what in case you compared pink tomatoes to yellow tomatoes, which have all the non-lycopene tomato compounds, to straight lycopene within a tablet?

So, they fed human beings red tomato paste, yellow tomato paste, lycopene tablets, or placebo capsules, and then dripped their blood on prostate most cancers cells growing within a petri dish.

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Compared to the ones not consuming anything, the red tomato serum, the blood from individuals who ate purple tomato paste, extensively reduced the prostate most cancers mobile’s expression of a increase-selling gene called cyclin D1.

This downregulation of the gene with the aid of the purple tomato intake “may make a contribution to decrease prostate cancer chance via proscribing cellular proliferation.” The purple tomato seemed to paintings higher than the yellow;

so, maybe the lycopene helped, however no longer in tablet shape. “[T]his gene was not regulated via [the lycopene-pill serum],” indicating that perhaps it’s something else.

And, lycopene alone notably upregulated “procarcinogenic genes.

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