Natural Carotene

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But, lycopene in supplement shape doesn’t appear to be powerful at lower doses, either.

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“There is a sturdy [protective] correlation between the consumption of [actual whole] fruit[s] and vegetables and the occurrence of certain cancers.” But while we complement with most effective a unmarried compound isolated in pill form, we may disappointed the healthy herbal balance of antioxidants. It does appear to be pretty the human hubris to assume we can reproduce “the beneficial results of consuming whole culmination and veggies” with the aid of giving supplements of a unmarried phytochemical, which would usually have interaction with thousands of other compounds within “the natural matrix” Mother Nature meant.

In addition to lycopene, different carotenoids within tomatoes consist of beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of which might be regarded “to build up in human prostate tissue.” And, “there also are numerous non–carotenoid compounds in tomatoes that [may] have [anti-cancer] pastime”—now not to say all of the compounds we've got but to even signify.

But, it’s not about finding the one magic bullet: “The anti-most cancers consequences of carotenoids and different phytonutrients can also reside in [their] combined activity.” For example, on the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene found within most people who consume ordinary amounts of tomatoes, there’s very little impact on most cancers cellular growth in vitro, used one by one.

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But integrate them all together, and a non-effective dose plus a non-powerful dose will become effective one way or the other, considerably suppressing prostate most cancers cellular growth.

And, the identical synergy can be visible throughout ingredients. Curcumin, the yellow pigment within turmeric and curry powder, tomato extracts, and the diet E discovered in nuts and seeds do little to inhibit seasoned-growth signaling of prostate most cancers cells—less than 10%.

But all three together suppresses increase signaling like 70%.

The whole is extra than the sum of its elements.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty- patients with localized prostate [cancer]” had been given three-quarters of a cup of canned tomato sauce every day “for three weeks…earlier than their scheduled radical prostatectomy.” In their bloodstream, PSA stages dropped “via 17.5%.” PSA, prostate-specific antigen, is a protein produced by means of prostate gland cells, and expanded blood levels are routinely used “to monitor the achievement of [cancer] remedy.

It changed into sudden to find that,” in only three weeks, a “tomato sauce-primarily based nutritional intervention” could lower PSA concentrations in guys with prostate cancer. Also, free radical damage of the DNA in their white blood cells dropped by using 21%.

Imagine how antioxidant-bad their food regimen should have been ahead, if less than a cup of tomato sauce an afternoon may want to lessen DNA harm by extra than a 5th.

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Okay, however what did they locate of their prostates? “[H]uman prostate tissue [is thought to] be especially vulnerable to oxidative DNA harm by unfastened radicals, which might be idea to play a critical function in all tiers of [cancer formation].” This may be for a number of motives, which includes “fewer DNA restore enzymes.” Well, the researchers had tissue samples taken before the tomato sauce from biopsies, and tissue samples after the three weeks of tomato sauce from the surgical operation, and resected tissues from tomato sauce-supplemented patients had 28% less loose radical damage than anticipated.

Here’s the DNA harm inside the prostate earlier than the tomato sauce, and here’s after.

Just 20 days of sauce. And, what’s thrilling is that “[t]right here changed into no affiliation among” the level of lycopene inside the prostate and the protecting consequences.

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Tomatoes incorporate a whole bunch of factors, some of which may be even extra effective than lycopene.

Regardless, in assessment to the lycopene dietary supplements by myself, “the whole-food intervention” seemed to help. To see if lycopene played any position at all, one could have to check a lycopene-loose tomato—within different phrases, a yellow tomato.

So, what if you compared red tomatoes to yellow tomatoes, that have all of the non-lycopene tomato compounds, to directly lycopene in a pill?

So, they fed human beings red tomato paste, yellow tomato paste, lycopene capsules, or placebo pills, after which dripped their blood on prostate most cancers cells growing in a petri dish.

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Compared to those not eating something, the purple tomato serum, the blood from those who ate red tomato paste, significantly decreased the prostate cancer cell’s expression of a boom-promoting gene known as cyclin D1.

This downregulation of the gene by means of the crimson tomato consumption “can also contribute to lower prostate cancer risk with the aid of restricting cell proliferation.” The purple tomato appeared to work higher than the yellow;

so, maybe the lycopene helped, but not in pill shape. “[T]his gene become now not regulated with the aid of [the lycopene-pill serum],” indicating that maybe it’s something else.

And, lycopene on my own extensively upregulated “procarcinogenic genes.

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