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But, lycopene within supplement form doesn’t appear to be effective at lower doses, both.

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“There is a strong [protective] correlation between the intake of [actual whole] fruit[s] and vegetables and the occurrence of sure cancers.” But when we supplement with only a unmarried compound remoted within pill form, we might also disillusioned the healthful herbal stability of antioxidants. It does appear to be pretty the human hubris to think we will reproduce “the beneficial effects of eating entire fruits and veggies” by using giving supplements of a single phytochemical, which could normally have interaction with thousands of other compounds in “the herbal matrix” Mother Nature supposed.

In addition to lycopene, different carotenoids within tomatoes consist of beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of that are recognised “to accumulate in human prostate tissue.” And, “there are also numerous non–carotenoid compounds within tomatoes that [may] have [anti-cancer] interest”—no longer to say all of the compounds we've got yet to even represent.

But, it’s no longer approximately locating the only magic bullet: “The anti-most cancers results of carotenoids and different phytonutrients may reside within [their] blended pastime.” For instance, at the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene located in most people who eat normal quantities of tomatoes, there’s very little effect on most cancers cellular growth in vitro, used separately.

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But combine all of them collectively, and a non-powerful dose plus a non-effective dose turns into effective one way or the other, considerably suppressing prostate most cancers cellular boom.

And, the equal synergy may be visible across ingredients. Curcumin, the yellow pigment in turmeric and curry powder, tomato extracts, and the nutrition E determined within nuts and seeds do little to inhibit pro-boom signaling of prostate cancer cells—much less than 10%.

But all three together suppresses growth signaling like 70%.

The entire is more than the sum of its parts.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty- sufferers with localized prostate [cancer]” have been given three-quarters of a cup of canned tomato sauce each day “for 3 weeks…before their scheduled radical prostatectomy.” In their bloodstream, PSA degrees dropped “by using 17.5%.” PSA, prostate-particular antigen, is a protein produced by way of prostate gland cells, and improved blood ranges are automatically used “to monitor the achievement of [cancer] treatment.

It become unexpected to find that,” in just three weeks, a “tomato sauce-primarily based dietary intervention” may want to decrease PSA concentrations within men with prostate most cancers. Also, unfastened radical harm of the DNA in their white blood cells dropped by using 21%.

Imagine how antioxidant-negative their food plan ought to were ahead, if much less than a cup of tomato sauce an afternoon should lessen DNA damage by extra than a 5th.

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Okay, however what did they locate in their prostates? “[H]uman prostate tissue [is thought to] be mainly liable to oxidative DNA damage by using free radicals, which are concept to play a critical position in all tiers of [cancer formation].” This may be for some of motives, such as “fewer DNA repair enzymes.” Well, the researchers had tissue samples taken before the tomato sauce from biopsies, and tissue samples after the 3 weeks of tomato sauce from the surgical treatment, and resected tissues from tomato sauce-supplemented patients had 28% less loose radical harm than predicted.

Here’s the DNA harm inside the prostate earlier than the tomato sauce, and right here’s after.

Just 20 days of sauce. And, what’s exciting is that “[t]right here became no association among” the level of lycopene within the prostate and the protective results.

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Tomatoes comprise an entire bunch of things, a number of which can be even more effective than lycopene.

Regardless, in comparison to the lycopene supplements alone, “the complete-meals intervention” regarded to assist. To see if lycopene performed any role at all, one could have to check a lycopene-unfastened tomato—within other words, a yellow tomato.

So, what if you in comparison crimson tomatoes to yellow tomatoes, that have all of the non-lycopene tomato compounds, to straight lycopene in a tablet?

So, they fed human beings red tomato paste, yellow tomato paste, lycopene capsules, or placebo capsules, after which dripped their blood on prostate most cancers cells growing in a petri dish.

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Compared to the ones no longer consuming something, the pink tomato serum, the blood from individuals who ate purple tomato paste, significantly reduced the prostate cancer mobile’s expression of a growth-promoting gene referred to as cyclin D1.

This downregulation of the gene by using the pink tomato intake “may also contribute to lower prostate cancer hazard by way of limiting cellular proliferation.” The pink tomato regarded to paintings higher than the yellow;

so, perhaps the lycopene helped, but now not in tablet form. “[T]his gene changed into no longer regulated with the aid of [the lycopene-pill serum],” indicating that maybe it’s something else.

And, lycopene by myself considerably upregulated “procarcinogenic genes.

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