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First of all, do those bovine casomorphins form inside the human digestive tract whilst we drink milk?

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Researchers decided to stick tubes down into human beings’s intestines to discover. And indeed, “[c]onsiderable quantities of…casomorphin…had been discovered.” Okay, however do they get absorbed into the bloodstream?

Yes, reputedly so.

But, this research become on toddlers, who evidently have leakier guts. Do completely intact casein-protein fragments make it into the bloodstream after infancy?

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Yes, even into adulthood, raising tiers in the blood for at least eight hours after intake.

And, those with autism can also have an specially leaky gut—at notably higher danger for abnormally excessive intestinal permeability, which may additionally provide an explanation for why the massive most of the autistic youngsters can also have antibodies in their blood to wheat and dairy proteins, in comparison to a small minority of everyday youngsters. And, based on allergy reviews, even though an toddler is exactly breastfed, they will still be exposed to bits of bovine milk proteins if the mom drinks milk, as the bovine protein fragments can get into her blood, then her breast, then into her toddler’s frame.

But, does it get into the baby’s mind?

Yeah, those with autism are much more likely to suffer from leaky intestine, but the so-referred to as “opioid excess concept” depends on casomorphins now not handiest moving into the bloodstream, however up into the critical worried machine, the brain.

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And, there’s some thing referred to as the blood-mind barrier that facilitates cordon off the mind.

When you take a look at the brain tissues of these with autism, their blood-mind barrier appears leakier, too.

And indeed, evidence for the presence of casomorphins inside the brains of infants has in view that “been showed”—which, again, simply makes sense. That’s the whole presumed point of casomorphin opioids—to have an effect on the brains of babies, so they crave the milk, cry out for the milk, strengthening the mom-little one bond, the cow-calf bond.

That’s what’s supposed to show up;

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it’s normal, natural. Okay, then, why are casomorphins related to ailment?

Well, this is regular and natural.

This? Not a lot.

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Human infants with proof of better baseline degrees of bovine casomorphins in their blood appear much more likely to be tormented by psychomotor delay, which is a measure of muscle, language, and intellectual function development.

But the opposite become found for human toddler publicity to human casomorphins—meaning human casomorphins seemed to be useful in human beings. See, just like bovine casomorphin levels inside the toddler’s blood appear to upward push after feeding cow’s milk formula, human casomorphin degrees upward thrust within the child after breastfeeding, and that’s what’s imagined to occur.

“The finest [baseline human casomorphins] changed into revealed in breastfed infants with normal psychomotor development and muscle tone.

In evaluation, expanded [baseline bovine casomorphins] found in [cow’s milk-]formula-fed toddlers [was associated with] postpone[ed] psychomotor development” and stiffened, greater rigid, muscle tone.

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“The rationalization of [the] opposite outcomes of human [versus] bovine [casomorphins] on toddler… development…likely [has to do with] species-specificity.” Cow’s milk is good for calves;

breast milk is good for infants.

“Indeed, the structure of bovine and human [casein is dramatically different],” and the bovine and human casomorphins themselves are extraordinary molecules, differing via  amino acids, which results in substantially different potencies. Compared to human casomorphin, bovine casomorphin “is surprisingly powerful and [more] similar to morphine in its effects.” A two-amino acid difference doesn’t seem like loads, however casomorphins are simplest seven amino acids long!

This 30% or so distinction “probable defines [the] distinction in their organic properties.

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Both human and bovine [casomorphins]…engage with opioid and serotonin receptors, which might be known to be of superb significance for [brain] maturation.” But cow casomorphin binds tighter to those receptors and, so, has more of an effect. This can, consequently, assist give an explanation for not best why breast is first-class, however the psychomotor delay linked with higher bovine casomorphin ranges in the blood helps this concept that cow casomorphins may additionally play a position in a ailment inclusive of autism.

This is why bovine casomorphins were known as “the satan within the milk.” But, are they formed from all cow’s milk?

What approximately so-called “A2” milk? The “A2 [milk] Corporation” points out there are specific “variations” of casein.

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Some cows produce milk with a sort of casein dubbed A1, and other cows offer milk with A2 casein, which differs from A1 casein “by a unmarried amino acid”—but strategically located such that A1 casein breaks down into casomorphin, which acts like morphine, “and is implicated within digestive, immune, and mind development modifications.” But, supposedly, A2 milk does now not.

Put A1 milk within a check tube with some digestive enzymes, and the A1 casein breaks down into casomorphin. But, because of that amino acid distinction, the A2 casein breaks down at a exceptional spot.

And so, no casomorphin is shaped.

But, this changed into the use of digestive enzymes from pigs, or cows, which are simply cheaper and less complicated to buy for laboratory experiments.

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But human digestive juices are exceptional.

And so, what takes place in a pig’s stomach or cow stomachs won't necessarily be what happens inside the human digestive tract.

But, the A1 as opposed to A2 breakdown experiment had never been accomplished with human enzymes before, until…now. Human stomach and intestinal juices were accrued, and the satan turned into within each.

The opioid casomorphin become constructed from each A1 and A2 milk.