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But, lycopene within supplement form doesn’t seem like powerful at decrease doses, either.

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“There is a robust [protective] correlation among the intake of [actual whole] fruit[s] and vegetables and the occurrence of sure cancers.” But whilst we complement with best a single compound remoted in pill form, we may also dissatisfied the wholesome natural balance of antioxidants. It does appear to be quite the human hubris to suppose we can reproduce “the beneficial consequences of ingesting entire end result and greens” through giving supplements of a single phytochemical, which might generally engage with heaps of other compounds in “the herbal matrix” Mother Nature supposed.

In addition to lycopene, different carotenoids in tomatoes consist of beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of which can be recognized “to build up in human prostate tissue.” And, “there are also severa non–carotenoid compounds in tomatoes that [may] have [anti-cancer] pastime”—not to say all the compounds we've got yet to even represent.

But, it’s now not about finding the one magic bullet: “The anti-most cancers outcomes of carotenoids and different phytonutrients may also reside within [their] mixed hobby.” For instance, on the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene discovered within most of the people who eat everyday quantities of tomatoes, there’s very little effect on most cancers cellular increase within vitro, used one at a time.

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But integrate all of them together, and a non-powerful dose plus a non-effective dose turns into effective by some means, notably suppressing prostate cancer cellular growth.

And, the equal synergy may be seen throughout meals. Curcumin, the yellow pigment in turmeric and curry powder, tomato extracts, and the nutrition E observed within nuts and seeds do little to inhibit pro-growth signaling of prostate most cancers cells—less than 10%.

But all three together suppresses boom signaling like 70%.

The whole is extra than the sum of its elements.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty-two sufferers with localized prostate [cancer]” were given three-quarters of a cup of canned tomato sauce every day “for 3 weeks…earlier than their scheduled radical prostatectomy.” In their bloodstream, PSA degrees dropped “by 17.5%.” PSA, prostate-precise antigen, is a protein produced by using prostate gland cells, and improved blood stages are routinely used “to screen the success of [cancer] treatment.

It became surprising to locate that,” in just three weeks, a “tomato sauce-primarily based nutritional intervention” should decrease PSA concentrations within men with prostate cancer. Also, unfastened radical damage of the DNA of their white blood cells dropped by using 21%.

Imagine how antioxidant-poor their food regimen must were in advance, if less than a cup of tomato sauce an afternoon should lessen DNA damage through extra than a fifth.

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Okay, but what did they find of their prostates? “[H]uman prostate tissue [is thought to] be particularly at risk of oxidative DNA harm via free radicals, which are thought to play a essential role within all tiers of [cancer formation].” This may be for a number of reasons, which include “fewer DNA restore enzymes.” Well, the researchers had tissue samples taken before the tomato sauce from biopsies, and tissue samples after the 3 weeks of tomato sauce from the surgical procedure, and resected tissues from tomato sauce-supplemented sufferers had 28% less unfastened radical harm than anticipated.

Here’s the DNA harm within the prostate earlier than the tomato sauce, and here’s after.

Just 20 days of sauce. And, what’s thrilling is that “[t]right here turned into no association between” the extent of lycopene inside the prostate and the protecting results.

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Tomatoes incorporate an entire bunch of things, a number of which can be even more powerful than lycopene.

Regardless, within evaluation to the lycopene dietary supplements on my own, “the entire-food intervention” regarded to assist. To see if lycopene performed any position at all, one could have to check a lycopene-free tomato—in different words, a yellow tomato.

So, what in case you compared pink tomatoes to yellow tomatoes, that have all the non-lycopene tomato compounds, to straight lycopene in a tablet?

So, they fed humans crimson tomato paste, yellow tomato paste, lycopene pills, or placebo drugs, and then dripped their blood on prostate cancer cells developing in a petri dish.

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Compared to the ones now not consuming something, the purple tomato serum, the blood from folks who ate purple tomato paste, considerably reduced the prostate most cancers mobile’s expression of a boom-selling gene known as cyclin D1.

This downregulation of the gene by means of the red tomato intake “may additionally make a contribution to lower prostate cancer risk with the aid of limiting cellular proliferation.” The crimson tomato regarded to paintings higher than the yellow;

so, maybe the lycopene helped, but now not within tablet shape. “[T]his gene was no longer regulated with the aid of [the lycopene-pill serum],” indicating that maybe it’s some thing else.

And, lycopene alone notably upregulated “procarcinogenic genes.

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