Reduce Free Radicals

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But, lycopene within complement shape doesn’t appear to be effective at decrease doses, either.

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“There is a sturdy [protective] correlation between the intake of [actual whole] fruit[s] and vegetables and the occurrence of certain cancers.” But whilst we supplement with most effective a single compound remoted in tablet shape, we may additionally dissatisfied the healthful natural balance of antioxidants. It does appear to be quite the human hubris to assume we are able to reproduce “the beneficial results of consuming entire culmination and vegetables” by giving dietary supplements of a single phytochemical, which might typically have interaction with hundreds of other compounds in “the natural matrix” Mother Nature supposed.

In addition to lycopene, different carotenoids within tomatoes consist of beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of that are recognized “to accumulate within human prostate tissue.” And, “there are also numerous non–carotenoid compounds within tomatoes that [may] have [anti-cancer] interest”—no longer to mention all of the compounds we have yet to even characterize.

But, it’s no longer about locating the only magic bullet: “The anti-cancer results of carotenoids and different phytonutrients may additionally are living in [their] combined activity.” For instance, at the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene observed within the general public who consume everyday quantities of tomatoes, there’s little or no effect on most cancers cellular growth in vitro, used one after the other.

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But integrate all of them collectively, and a non-powerful dose plus a non-powerful dose will become effective by some means, drastically suppressing prostate cancer mobile boom.

And, the same synergy may be seen across meals. Curcumin, the yellow pigment within turmeric and curry powder, tomato extracts, and the diet E observed within nuts and seeds do little to inhibit pro-increase signaling of prostate most cancers cells—much less than 10%.

But all three collectively suppresses increase signaling like 70%.

The complete is extra than the sum of its components.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty-two patients with localized prostate [cancer]” have been given three-quarters of a cup of canned tomato sauce every day “for three weeks…before their scheduled radical prostatectomy.” In their bloodstream, PSA tiers dropped “via 17.5%.” PSA, prostate-specific antigen, is a protein produced via prostate gland cells, and expanded blood degrees are mechanically used “to screen the fulfillment of [cancer] remedy.

It become surprising to discover that,” in just three weeks, a “tomato sauce-primarily based nutritional intervention” ought to decrease PSA concentrations within men with prostate cancer. Also, unfastened radical damage of the DNA in their white blood cells dropped through 21%.

Imagine how antioxidant-poor their food plan must had been beforehand, if much less than a cup of tomato sauce an afternoon may want to lessen DNA damage through greater than a fifth.

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Okay, however what did they discover of their prostates? “[H]uman prostate tissue [is thought to] be especially vulnerable to oxidative DNA damage by using loose radicals, which can be idea to play a essential position in all ranges of [cancer formation].” This may be for some of reasons, inclusive of “fewer DNA repair enzymes.” Well, the researchers had tissue samples taken before the tomato sauce from biopsies, and tissue samples after the 3 weeks of tomato sauce from the surgical procedure, and resected tissues from tomato sauce-supplemented sufferers had 28% less unfastened radical damage than expected.

Here’s the DNA damage inside the prostate before the tomato sauce, and right here’s after.

Just 20 days of sauce. And, what’s interesting is that “[t]right here turned into no association among” the level of lycopene inside the prostate and the protective consequences.

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Tomatoes comprise a whole bunch of things, some of which may be even extra effective than lycopene.

Regardless, within comparison to the lycopene dietary supplements alone, “the complete-meals intervention” appeared to help. To see if lycopene performed any function in any respect, one could have to test a lycopene-unfastened tomato—within different phrases, a yellow tomato.

So, what in case you compared pink tomatoes to yellow tomatoes, that have all the non-lycopene tomato compounds, to immediately lycopene within a pill?

So, they fed humans purple tomato paste, yellow tomato paste, lycopene tablets, or placebo tablets, and then dripped their blood on prostate most cancers cells growing within a petri dish.

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Compared to the ones no longer consuming anything, the crimson tomato serum, the blood from folks that ate crimson tomato paste, significantly reduced the prostate most cancers mobile’s expression of a boom-promoting gene referred to as cyclin D1.

This downregulation of the gene by the purple tomato consumption “may additionally make a contribution to decrease prostate most cancers threat by way of limiting cellular proliferation.” The crimson tomato seemed to work better than the yellow;

so, perhaps the lycopene helped, but now not in tablet shape. “[T]his gene turned into now not regulated with the aid of [the lycopene-pill serum],” indicating that perhaps it’s something else.

And, lycopene by myself drastically upregulated “procarcinogenic genes.

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