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But, lycopene within supplement shape doesn’t seem like effective at lower doses, either.

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“There is a strong [protective] correlation among the consumption of [actual whole] fruit[s] and vegetables and the occurrence of positive cancers.” But whilst we supplement with simplest a single compound isolated within tablet shape, we may additionally disappointed the healthful natural stability of antioxidants. It does seem to be pretty the human hubris to think we will reproduce “the beneficial consequences of consuming entire culmination and greens” by using giving dietary supplements of a single phytochemical, which would commonly have interaction with lots of different compounds within “the herbal matrix” Mother Nature meant.

In addition to lycopene, other carotenoids in tomatoes consist of beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of which might be known “to accumulate within human prostate tissue.” And, “there also are numerous non–carotenoid compounds in tomatoes that [may] have [anti-cancer] activity”—no longer to say all the compounds we have yet to even symbolize.

But, it’s no longer about locating the only magic bullet: “The anti-cancer consequences of carotenoids and other phytonutrients might also live within [their] combined pastime.” For instance, on the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene discovered within the majority who consume everyday amounts of tomatoes, there’s little or no impact on cancer mobile boom within vitro, used separately.

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But integrate all of them together, and a non-effective dose plus a non-effective dose will become powerful in some way, extensively suppressing prostate cancer cell growth.

And, the same synergy may be seen throughout ingredients. Curcumin, the yellow pigment within turmeric and curry powder, tomato extracts, and the vitamin E found within nuts and seeds do little to inhibit pro-growth signaling of prostate most cancers cells—much less than 10%.

But all three together suppresses increase signaling like 70%.

The whole is greater than the sum of its parts.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty- sufferers with localized prostate [cancer]” were given three-quarters of a cup of canned tomato sauce every day “for three weeks…earlier than their scheduled radical prostatectomy.” In their bloodstream, PSA tiers dropped “through 17.5%.” PSA, prostate-precise antigen, is a protein produced with the aid of prostate gland cells, and improved blood ranges are robotically used “to screen the achievement of [cancer] treatment.

It was surprising to find that,” in just three weeks, a “tomato sauce-primarily based nutritional intervention” could lower PSA concentrations within guys with prostate most cancers. Also, free radical harm of the DNA in their white blood cells dropped by means of 21%.

Imagine how antioxidant-terrible their weight loss plan have to had been in advance, if much less than a cup of tomato sauce an afternoon should lessen DNA harm by means of greater than a fifth.

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Okay, however what did they find of their prostates? “[H]uman prostate tissue [is thought to] be mainly at risk of oxidative DNA damage through free radicals, that are thought to play a essential role in all stages of [cancer formation].” This can be for some of motives, consisting of “fewer DNA repair enzymes.” Well, the researchers had tissue samples taken before the tomato sauce from biopsies, and tissue samples after the three weeks of tomato sauce from the surgery, and resected tissues from tomato sauce-supplemented patients had 28% less free radical harm than expected.

Here’s the DNA harm inside the prostate before the tomato sauce, and right here’s after.

Just 20 days of sauce. And, what’s exciting is that “[t]right here became no affiliation between” the level of lycopene inside the prostate and the protecting effects.

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Tomatoes comprise a whole bunch of factors, a number of which can be even extra effective than lycopene.

Regardless, within comparison to the lycopene supplements alone, “the complete-food intervention” appeared to help. To see if lycopene performed any position in any respect, one would have to check a lycopene-unfastened tomato—in other words, a yellow tomato.

So, what if you in comparison red tomatoes to yellow tomatoes, that have all the non-lycopene tomato compounds, to straight lycopene within a pill?

So, they fed humans purple tomato paste, yellow tomato paste, lycopene capsules, or placebo tablets, after which dripped their blood on prostate cancer cells developing within a petri dish.

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Compared to the ones no longer ingesting some thing, the crimson tomato serum, the blood from individuals who ate pink tomato paste, drastically reduced the prostate cancer cellular’s expression of a increase-promoting gene referred to as cyclin D1.

This downregulation of the gene with the aid of the pink tomato intake “may additionally make a contribution to decrease prostate cancer threat by using proscribing cellular proliferation.” The red tomato appeared to work better than the yellow;

so, maybe the lycopene helped, but now not in pill form. “[T]his gene become no longer regulated via [the lycopene-pill serum],” indicating that perhaps it’s something else.

And, lycopene on my own notably upregulated “procarcinogenic genes.

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