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But, lycopene in supplement shape doesn’t appear to be effective at decrease doses, both.

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“There is a sturdy [protective] correlation between the intake of [actual whole] fruit[s] and veggies and the incidence of sure cancers.” But when we complement with simplest a single compound remoted within tablet shape, we might also disenchanted the wholesome natural balance of antioxidants. It does seem to be pretty the human hubris to think we can reproduce “the beneficial consequences of ingesting complete end result and veggies” via giving supplements of a single phytochemical, which could generally interact with hundreds of other compounds in “the natural matrix” Mother Nature intended.

In addition to lycopene, different carotenoids in tomatoes consist of beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of that are acknowledged “to accumulate in human prostate tissue.” And, “there also are numerous non–carotenoid compounds in tomatoes that [may] have [anti-cancer] activity”—now not to mention all the compounds we have yet to even characterize.

But, it’s not about finding the only magic bullet: “The anti-cancer results of carotenoids and other phytonutrients can also live in [their] blended interest.” For example, on the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene found within the general public who consume everyday amounts of tomatoes, there’s very little effect on most cancers cellular boom in vitro, used one at a time.

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But integrate them all collectively, and a non-effective dose plus a non-effective dose becomes effective by some means, considerably suppressing prostate cancer cellular growth.

And, the same synergy may be visible throughout foods. Curcumin, the yellow pigment in turmeric and curry powder, tomato extracts, and the diet E discovered in nuts and seeds do little to inhibit seasoned-growth signaling of prostate cancer cells—much less than 10%.

But all three collectively suppresses boom signaling like 70%.

The whole is extra than the sum of its components.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty- patients with localized prostate [cancer]” were given three-quarters of a cup of canned tomato sauce each day “for three weeks…earlier than their scheduled radical prostatectomy.” In their bloodstream, PSA ranges dropped “through 17.5%.” PSA, prostate-particular antigen, is a protein produced by means of prostate gland cells, and elevated blood stages are automatically used “to reveal the success of [cancer] remedy.

It turned into unexpected to find that,” in only three weeks, a “tomato sauce-based nutritional intervention” should lower PSA concentrations in guys with prostate cancer. Also, unfastened radical damage of the DNA of their white blood cells dropped with the aid of 21%.

Imagine how antioxidant-terrible their food plan need to had been ahead, if much less than a cup of tomato sauce an afternoon may want to lessen DNA harm through more than a 5th.

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Okay, but what did they find in their prostates? “[H]uman prostate tissue [is thought to] be specifically vulnerable to oxidative DNA harm by way of free radicals, that are concept to play a important role in all degrees of [cancer formation].” This may be for some of motives, including “fewer DNA restore enzymes.” Well, the researchers had tissue samples taken before the tomato sauce from biopsies, and tissue samples after the three weeks of tomato sauce from the surgical treatment, and resected tissues from tomato sauce-supplemented patients had 28% much less free radical harm than expected.

Here’s the DNA harm inside the prostate before the tomato sauce, and right here’s after.

Just 20 days of sauce. And, what’s interesting is that “[t]here turned into no affiliation among” the level of lycopene in the prostate and the protective effects.

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Tomatoes incorporate a whole bunch of things, a number of which can be even greater effective than lycopene.

Regardless, in comparison to the lycopene dietary supplements on my own, “the whole-meals intervention” appeared to help. To see if lycopene played any position at all, one would have to test a lycopene-unfastened tomato—in other phrases, a yellow tomato.

So, what in case you as compared red tomatoes to yellow tomatoes, which have all of the non-lycopene tomato compounds, to straight lycopene in a pill?

So, they fed people red tomato paste, yellow tomato paste, lycopene capsules, or placebo capsules, after which dripped their blood on prostate most cancers cells developing within a petri dish.

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Compared to the ones now not ingesting anything, the pink tomato serum, the blood from folks who ate purple tomato paste, extensively reduced the prostate most cancers mobile’s expression of a increase-selling gene called cyclin D1.

This downregulation of the gene by the purple tomato intake “may additionally make contributions to decrease prostate most cancers danger through limiting cellular proliferation.” The crimson tomato appeared to work better than the yellow;

so, perhaps the lycopene helped, however no longer in pill shape. “[T]his gene was not regulated through [the lycopene-pill serum],” indicating that perhaps it’s some thing else.

And, lycopene by myself appreciably upregulated “procarcinogenic genes.

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