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They had been basically denied, with the FDA pronouncing that the evidence changed into “very restricted and preliminary,” with out a endorsement allowed for ketchup or supplements.

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By that point, similarly populace experiences had cast doubt at the lycopene concept. Consumers of high dietary intakes of lycopene didn’t seem to have lower cancer shares, in spite of everything.

But, who has excessive nutritional intakes of lycopene?

Those that eat the maximum pizza; so, perhaps it’s no wonder there are combined results.

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What we need is to place lycopene to the check.

It began with a case study. A 62-yr antique guy with terminal prostate cancer;

failed surgery, failed chemotherapy, metastases all over, unfold to the bone.

And so, he was sent to hospice to die.

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So, he took it upon himself to provoke “phytotherapy”—plant-based totally remedy, taking the amount of lycopene discovered within 1 / 4-cup of tomato sauce, or a tablespoon of tomato paste each day.

His PSA, a degree of tumor bulk, began out at 365, dropped to 140 the next month, after which all the way down to 8.

His metastases commenced disappearing, and, as of his closing observe-up, regarded to be living happily ever after. But, whilst given within higher-dose tablet shape, it didn’t seem to work.

A 2013 evaluate of all such lycopene supplement trials “didn't guide [the initial] optimism.” In reality, they had been just glad that the lycopene capsules didn’t turn out to be causing more most cancers, like beta-carotene tablets did.

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But, then came 2014. Researchers within Italy have been giving the most important doses they may of lycopene, selenium, and isolated green tea compounds to guys with precancerous prostate lesions, hoping they could prevent complete-blown cancer.

But, in 2014, the elevated results of a comparable trial had been posted, in which selenium and diet E dietary supplements resulted in more most cancers.

Yikes! So, these researchers stopped their trial, and broke the code to unblind the outcomes, And certainly, the ones taking high doses of lycopene, inexperienced tea catechins, and selenium seemed to get more cancer than individuals who just were given sugar pills.

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“The potential implications are dramatic,” said the lead researcher, “given the present day big global use of such compounds as alleged preventive supplements in prostate and different cancers.” What went wrong?

Well, after the beta-carotene pill debacle, researchers measured mobile damage at different natural and unnatural doses of beta-carotene. At dietary doses, beta-carotene suppressed cell damage, however at higher, supplemental doses, it now not most effective appeared to forestall running, however precipitated more harm.

And, the identical with lycopene.

“Both lycopene and [beta]-carotene afforded protection against DNA damage” at the sorts of stages one would possibly see in human beings eating masses of tomatoes or candy potatoes—”degrees…similar with the ones seen within the [blood] of people who eat a carotenoid-wealthy healthy food plan.” However, on the form of blood concentrations that one might get taking capsules, “the potential to shield the cells in opposition to such [free radical] damage become hastily misplaced, and, certainly, the presence of [high levels of beta-carotene and lycopene] may additionally truly serve to increase the volume of DNA damage.” So, no wonder excessive-dose lycopene pills didn’t paintings.

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“Phytochemicals [may be] guardians of our fitness,” but “[t]he safety of consuming concentrated extracts…is unknown.” The shielding advantages of a phytochemical-wealthy weight loss program is fine acquired [through whole plant foods].” The food industry has extraordinary thoughts, although.