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But, lycopene in supplement form doesn’t look like powerful at decrease doses, both.

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“There is a robust [protective] correlation among the consumption of [actual whole] fruit[s] and veggies and the occurrence of certain cancers.” But when we complement with handiest a single compound remoted within tablet shape, we might also upset the wholesome natural stability of antioxidants. It does appear to be quite the human hubris to assume we can reproduce “the beneficial effects of ingesting entire culmination and veggies” with the aid of giving dietary supplements of a single phytochemical, which would generally interact with thousands of different compounds in “the herbal matrix” Mother Nature supposed.

In addition to lycopene, other carotenoids within tomatoes encompass beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of which are known “to build up within human prostate tissue.” And, “there also are severa non–carotenoid compounds in tomatoes that [may] have [anti-cancer] activity”—no longer to mention all the compounds we've yet to even signify.

But, it’s no longer about locating the only magic bullet: “The anti-cancer consequences of carotenoids and different phytonutrients may also reside within [their] combined hobby.” For example, on the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene observed in the majority who eat everyday amounts of tomatoes, there’s very little effect on cancer cellular boom in vitro, used one at a time.

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But combine them all collectively, and a non-powerful dose plus a non-powerful dose will become effective in some way, notably suppressing prostate most cancers mobile increase.

And, the equal synergy may be visible across ingredients. Curcumin, the yellow pigment in turmeric and curry powder, tomato extracts, and the nutrition E located in nuts and seeds do little to inhibit pro-growth signaling of prostate cancer cells—much less than 10%.

But all three collectively suppresses increase signaling like 70%.

The whole is extra than the sum of its components.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty-two patients with localized prostate [cancer]” had been given three-quarters of a cup of canned tomato sauce each day “for 3 weeks…before their scheduled radical prostatectomy.” In their bloodstream, PSA tiers dropped “by means of 17.5%.” PSA, prostate-unique antigen, is a protein produced with the aid of prostate gland cells, and increased blood degrees are mechanically used “to reveal the success of [cancer] remedy.

It changed into sudden to find that,” in only three weeks, a “tomato sauce-primarily based dietary intervention” ought to decrease PSA concentrations in guys with prostate most cancers. Also, free radical harm of the DNA in their white blood cells dropped by 21%.

Imagine how antioxidant-bad their food plan need to were beforehand, if less than a cup of tomato sauce a day should reduce DNA damage through extra than a fifth.

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Okay, however what did they locate of their prostates? “[H]uman prostate tissue [is thought to] be in particular at risk of oxidative DNA harm by way of unfastened radicals, which might be idea to play a important role in all stages of [cancer formation].” This may be for some of motives, such as “fewer DNA restore enzymes.” Well, the researchers had tissue samples taken earlier than the tomato sauce from biopsies, and tissue samples after the 3 weeks of tomato sauce from the surgical procedure, and resected tissues from tomato sauce-supplemented sufferers had 28% less free radical harm than predicted.

Here’s the DNA harm within the prostate earlier than the tomato sauce, and right here’s after.

Just 20 days of sauce. And, what’s interesting is that “[t]here changed into no association between” the level of lycopene in the prostate and the protective outcomes.

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Tomatoes contain a whole bunch of things, some of which can be even more effective than lycopene.

Regardless, within contrast to the lycopene dietary supplements alone, “the entire-meals intervention” seemed to assist. To see if lycopene performed any position at all, one might have to check a lycopene-loose tomato—in different phrases, a yellow tomato.

So, what if you compared purple tomatoes to yellow tomatoes, that have all the non-lycopene tomato compounds, to immediately lycopene in a pill?

So, they fed people pink tomato paste, yellow tomato paste, lycopene drugs, or placebo drugs, and then dripped their blood on prostate most cancers cells growing within a petri dish.

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Compared to the ones not consuming some thing, the red tomato serum, the blood from those who ate pink tomato paste, substantially decreased the prostate most cancers cellular’s expression of a boom-promoting gene called cyclin D1.

This downregulation of the gene via the red tomato consumption “may also contribute to decrease prostate cancer danger by using proscribing mobile proliferation.” The crimson tomato seemed to work better than the yellow;

so, maybe the lycopene helped, however now not within pill shape. “[T]his gene changed into no longer regulated with the aid of [the lycopene-pill serum],” indicating that maybe it’s some thing else.

And, lycopene alone significantly upregulated “procarcinogenic genes.

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