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But, lycopene in supplement form doesn’t appear to be effective at decrease doses, either.

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“There is a strong [protective] correlation among the intake of [actual whole] fruit[s] and vegetables and the incidence of positive cancers.” But when we supplement with most effective a single compound isolated within pill form, we may dissatisfied the healthful herbal stability of antioxidants. It does appear to be pretty the human hubris to suppose we are able to reproduce “the beneficial results of eating entire culmination and veggies” through giving dietary supplements of a unmarried phytochemical, which would commonly have interaction with thousands of other compounds in “the herbal matrix” Mother Nature supposed.

In addition to lycopene, other carotenoids in tomatoes encompass beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of which are regarded “to build up within human prostate tissue.” And, “there are also numerous non–carotenoid compounds in tomatoes that [may] have [anti-cancer] hobby”—no longer to mention all the compounds we've got but to even symbolize.

But, it’s now not about finding the only magic bullet: “The anti-most cancers effects of carotenoids and other phytonutrients can also reside in [their] mixed hobby.” For example, on the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene observed within the majority who consume everyday amounts of tomatoes, there’s very little effect on cancer cell boom within vitro, used one at a time.

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But combine all of them collectively, and a non-effective dose plus a non-effective dose turns into effective someway, notably suppressing prostate cancer cell boom.

And, the identical synergy may be seen across ingredients. Curcumin, the yellow pigment in turmeric and curry powder, tomato extracts, and the nutrition E found in nuts and seeds do little to inhibit pro-increase signaling of prostate most cancers cells—less than 10%.

But all three collectively suppresses growth signaling like 70%.

The whole is more than the sum of its components.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty- patients with localized prostate [cancer]” had been given three-quarters of a cup of canned tomato sauce every day “for 3 weeks…earlier than their scheduled radical prostatectomy.” In their bloodstream, PSA stages dropped “through 17.5%.” PSA, prostate-specific antigen, is a protein produced by way of prostate gland cells, and extended blood tiers are robotically used “to screen the fulfillment of [cancer] remedy.

It turned into sudden to discover that,” in only three weeks, a “tomato sauce-based totally nutritional intervention” ought to decrease PSA concentrations within men with prostate most cancers. Also, unfastened radical harm of the DNA in their white blood cells dropped by means of 21%.

Imagine how antioxidant-bad their eating regimen ought to were in advance, if much less than a cup of tomato sauce an afternoon ought to lessen DNA damage by means of greater than a fifth.

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Okay, but what did they discover of their prostates? “[H]uman prostate tissue [is thought to] be mainly liable to oxidative DNA damage through free radicals, which are idea to play a essential position within all stages of [cancer formation].” This may be for some of reasons, which include “fewer DNA restore enzymes.” Well, the researchers had tissue samples taken before the tomato sauce from biopsies, and tissue samples after the 3 weeks of tomato sauce from the surgery, and resected tissues from tomato sauce-supplemented patients had 28% much less free radical damage than anticipated.

Here’s the DNA damage in the prostate before the tomato sauce, and right here’s after.

Just 20 days of sauce. And, what’s interesting is that “[t]right here become no association between” the level of lycopene in the prostate and the protective outcomes.

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Tomatoes include an entire bunch of things, some of which may be even greater powerful than lycopene.

Regardless, in comparison to the lycopene dietary supplements on my own, “the entire-food intervention” regarded to assist. To see if lycopene played any position in any respect, one would have to test a lycopene-loose tomato—within different phrases, a yellow tomato.

So, what if you in comparison pink tomatoes to yellow tomatoes, that have all the non-lycopene tomato compounds, to straight lycopene within a pill?

So, they fed humans pink tomato paste, yellow tomato paste, lycopene capsules, or placebo drugs, and then dripped their blood on prostate cancer cells developing within a petri dish.

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Compared to the ones no longer eating something, the crimson tomato serum, the blood from folks who ate crimson tomato paste, considerably decreased the prostate cancer cellular’s expression of a growth-promoting gene referred to as cyclin D1.

This downregulation of the gene through the red tomato consumption “may also make contributions to lower prostate cancer threat through proscribing cellular proliferation.” The pink tomato seemed to work higher than the yellow;

so, perhaps the lycopene helped, but not in pill shape. “[T]his gene turned into now not regulated by [the lycopene-pill serum],” indicating that maybe it’s some thing else.

And, lycopene on my own extensively upregulated “procarcinogenic genes.

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