A Molecule Related To Obesity Has Been Found
Author: Karen Lennox
Time for reading: ~1
minutes
Last Updated:
August 08, 2022
The Bsx molecule is the reason why the same diet leads to obesity in some and not in others.
The Bsx molecule is the reason why the same diet leads to obesity in some and not in others. This was published in the latest issue of the journal Cell Metabolism by scientists at the Institute of Molecular Biology in Potsdam, Germany.
Bsx is a molecular link between physical activity and diet. in mice, its absence has been found to lead to lower spontaneous physical activity, a different response to hunger, and a lower concentration of dietary hormones in the brain than in mice. Scientists hope to use this molecule to control diet-induced obesity.
Spontaneous physical activity, various unconscious movements, along with caloric intake are especially important for the regulation of body weight. They are controlled by the hypothalamus and are interconnected. For example, when we are hungry, spontaneous activity increases and we go out to eat. In fact, scientists have discovered the molecule that makes the connection between locomotor activity and nutrition, in this case in mice. Those with Bsx deficiency are significantly lazier and have depressed food-seeking behavior. This is due to the lowering of the levels of hormones in the brain that are stimulated by this molecule - NPY and AgRP. The latter leads to inaction on the part of mice even if they die of starvation. In addition, Bsx is thought to be needed for the sensitivity of brain cells to hunger, which means that they do not feel the need to eat at all.
It is very possible that this molecule has a similar effect in humans. The difference in it between individuals would clarify why some people are more active than others and why it is easier to gain weight with an irrational diet.
These data can radically change the approach to obesity and related cardiovascular diseases and diabetes. The development of drugs targeted to the molecule would modulate metabolism as well as motor activity in people in whom obesity is the result of irrational eating.
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