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But, lycopene in complement shape doesn’t look like powerful at lower doses, either.

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“There is a strong [protective] correlation between the consumption of [actual whole] fruit[s] and greens and the prevalence of positive cancers.” But when we complement with simplest a single compound remoted within pill form, we may also disillusioned the healthful herbal balance of antioxidants. It does seem to be pretty the human hubris to suppose we will reproduce “the beneficial results of consuming entire end result and greens” by means of giving supplements of a unmarried phytochemical, which would normally engage with heaps of different compounds within “the natural matrix” Mother Nature meant.

In addition to lycopene, different carotenoids in tomatoes include beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of which might be recognised “to accumulate in human prostate tissue.” And, “there also are severa non–carotenoid compounds in tomatoes that [may] have [anti-cancer] hobby”—not to mention all the compounds we've got yet to even signify.

But, it’s now not about finding the one magic bullet: “The anti-cancer consequences of carotenoids and different phytonutrients may are living within [their] blended pastime.” For instance, on the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene located within most of the people who devour normal amounts of tomatoes, there’s little or no effect on cancer cellular growth within vitro, used one at a time.

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But integrate them all together, and a non-effective dose plus a non-effective dose will become effective someway, notably suppressing prostate most cancers mobile boom.

And, the identical synergy may be seen across ingredients. Curcumin, the yellow pigment in turmeric and curry powder, tomato extracts, and the vitamin E found within nuts and seeds do little to inhibit pro-boom signaling of prostate most cancers cells—less than 10%.

But all three collectively suppresses boom signaling like 70%.

The complete is greater than the sum of its parts.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty- sufferers with localized prostate [cancer]” have been given three-quarters of a cup of canned tomato sauce every day “for three weeks…before their scheduled radical prostatectomy.” In their bloodstream, PSA degrees dropped “by means of 17.5%.” PSA, prostate-precise antigen, is a protein produced via prostate gland cells, and improved blood levels are mechanically used “to reveal the achievement of [cancer] remedy.

It became unexpected to locate that,” in just three weeks, a “tomato sauce-primarily based nutritional intervention” should decrease PSA concentrations within guys with prostate cancer. Also, unfastened radical damage of the DNA of their white blood cells dropped by 21%.

Imagine how antioxidant-poor their food regimen need to were beforehand, if less than a cup of tomato sauce an afternoon may want to reduce DNA harm by means of extra than a fifth.

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Okay, but what did they find of their prostates? “[H]uman prostate tissue [is thought to] be in particular susceptible to oxidative DNA harm by means of free radicals, which might be thought to play a crucial role within all levels of [cancer formation].” This can be for some of reasons, including “fewer DNA restore enzymes.” Well, the researchers had tissue samples taken before the tomato sauce from biopsies, and tissue samples after the three weeks of tomato sauce from the surgical procedure, and resected tissues from tomato sauce-supplemented patients had 28% much less free radical damage than predicted.

Here’s the DNA damage in the prostate before the tomato sauce, and right here’s after.

Just 20 days of sauce. And, what’s interesting is that “[t]here changed into no association among” the level of lycopene within the prostate and the protecting consequences.

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Tomatoes incorporate an entire bunch of things, a number of which can be even more powerful than lycopene.

Regardless, in contrast to the lycopene dietary supplements on my own, “the complete-meals intervention” regarded to assist. To see if lycopene played any function at all, one could have to test a lycopene-free tomato—in different phrases, a yellow tomato.

So, what in case you as compared pink tomatoes to yellow tomatoes, that have all of the non-lycopene tomato compounds, to instantly lycopene in a tablet?

So, they fed humans purple tomato paste, yellow tomato paste, lycopene drugs, or placebo pills, after which dripped their blood on prostate cancer cells growing within a petri dish.

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Compared to the ones not consuming some thing, the purple tomato serum, the blood from folks who ate purple tomato paste, extensively reduced the prostate cancer mobile’s expression of a boom-promoting gene referred to as cyclin D1.

This downregulation of the gene by using the crimson tomato consumption “may additionally make contributions to decrease prostate cancer danger by way of restricting cellular proliferation.” The purple tomato seemed to work higher than the yellow;

so, maybe the lycopene helped, however no longer in pill shape. “[T]his gene become not regulated by means of [the lycopene-pill serum],” indicating that maybe it’s some thing else.

And, lycopene by myself significantly upregulated “procarcinogenic genes.

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