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They were essentially denied, with the FDA saying that the evidence became “very restricted and preliminary,” without a endorsement allowed for ketchup or supplements.

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By that point, further populace experiences had cast doubt at the lycopene theory. Consumers of high nutritional intakes of lycopene didn’t appear to have decrease cancer shares, after all.

But, who has high nutritional intakes of lycopene?

Those that eat the most pizza; so, maybe it’s no wonder there are combined effects.

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What we want is to place lycopene to the test.

It started out with a case poll. A 62-yr old man with terminal prostate cancer;

failed surgical procedure, failed chemotherapy, metastases throughout, unfold to the bone.

And so, he became despatched to hospice to die.

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So, he took it upon himself to provoke “phytotherapy”—plant-based totally remedy, taking the amount of lycopene observed within 1 / 4-cup of tomato sauce, or a tablespoon of tomato paste each day.

His PSA, a measure of tumor bulk, started out out at 365, dropped to 140 the following month, and then all the way down to 8.

His metastases commenced disappearing, and, as of his last observe-up, seemed to be residing happily ever after. But, when given in better-dose tablet shape, it didn’t seem to paintings.

A 2013 overview of all such lycopene complement trials “failed to aid [the initial] optimism.” In reality, they were just happy that the lycopene tablets didn’t end up inflicting greater most cancers, like beta-carotene drugs did.

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But, then got here 2014. Researchers in Italy were giving the most important doses they may of lycopene, selenium, and isolated inexperienced tea compounds to guys with precancerous prostate lesions, hoping they might prevent complete-blown most cancers.

But, in 2014, the elevated outcomes of a comparable trial had been published, wherein selenium and diet E dietary supplements led to extra most cancers.

Yikes! So, these researchers stopped their trial, and broke the code to unblind the results, And certainly, the ones taking excessive doses of lycopene, green tea catechins, and selenium regarded to get more most cancers than folks who just were given sugar drugs.

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“The potential implications are dramatic,” said the lead researcher, “given the modern massive worldwide use of such compounds as alleged preventive vitamins within prostate and different cancers.” What went wrong?

Well, after the beta-carotene tablet debacle, researchers measured cell harm at different herbal and unnatural doses of beta-carotene. At dietary doses, beta-carotene suppressed cell harm, however at better, supplemental doses, it no longer most effective regarded to prevent running, but prompted greater damage.

And, the same with lycopene.

“Both lycopene and [beta]-carotene afforded safety against DNA harm” at the styles of ranges one might see within humans eating lots of tomatoes or candy potatoes—”stages…similar with the ones seen inside the [blood] of folks that devour a carotenoid-rich healthy weight loss program.” However, on the type of blood concentrations that one would possibly get taking capsules, “the ability to shield the cells towards such [free radical] damage changed into swiftly lost, and, indeed, the presence of [high levels of beta-carotene and lycopene] can also truly serve to boom the volume of DNA damage.” So, no wonder excessive-dose lycopene capsules didn’t paintings.

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“Phytochemicals [may be] guardians of our health,” but “[t]he protection of consuming concentrated extracts…is unknown.” The defensive advantages of a phytochemical-rich eating regimen is pleasant obtained [through whole plant foods].” The food enterprise has different ideas, even though.