Best Natural Antioxidant

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But, lycopene in supplement form doesn’t look like powerful at decrease doses, either.

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“There is a robust [protective] correlation between the consumption of [actual whole] fruit[s] and vegetables and the prevalence of positive cancers.” But when we complement with handiest a single compound isolated within pill form, we may additionally upset the wholesome natural balance of antioxidants. It does seem to be pretty the human hubris to assume we will reproduce “the useful effects of ingesting complete fruits and veggies” by means of giving supplements of a unmarried phytochemical, which could commonly interact with thousands of other compounds within “the herbal matrix” Mother Nature meant.

In addition to lycopene, other carotenoids within tomatoes consist of beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of which can be recognised “to build up within human prostate tissue.” And, “there also are numerous non–carotenoid compounds in tomatoes that [may] have [anti-cancer] interest”—no longer to say all of the compounds we've but to even signify.

But, it’s no longer approximately locating the one magic bullet: “The anti-cancer effects of carotenoids and different phytonutrients can also are living within [their] blended interest.” For example, on the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene discovered in most people who devour everyday amounts of tomatoes, there’s very little impact on cancer mobile increase in vitro, used separately.

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But combine them all together, and a non-powerful dose plus a non-powerful dose becomes effective by some means, appreciably suppressing prostate cancer cell boom.

And, the identical synergy can be seen across ingredients. Curcumin, the yellow pigment in turmeric and curry powder, tomato extracts, and the diet E located within nuts and seeds do little to inhibit seasoned-boom signaling of prostate most cancers cells—much less than 10%.

But all three collectively suppresses increase signaling like 70%.

The complete is more than the sum of its parts.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty-two sufferers with localized prostate [cancer]” have been given three-quarters of a cup of canned tomato sauce every day “for 3 weeks…earlier than their scheduled radical prostatectomy.” In their bloodstream, PSA degrees dropped “with the aid of 17.5%.” PSA, prostate-precise antigen, is a protein produced by way of prostate gland cells, and accelerated blood levels are mechanically used “to screen the success of [cancer] treatment.

It became surprising to locate that,” in only three weeks, a “tomato sauce-based nutritional intervention” could lower PSA concentrations in guys with prostate cancer. Also, free radical harm of the DNA of their white blood cells dropped with the aid of 21%.

Imagine how antioxidant-negative their weight-reduction plan ought to have been beforehand, if less than a cup of tomato sauce an afternoon should lessen DNA damage through extra than a fifth.

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Okay, however what did they find of their prostates? “[H]uman prostate tissue [is thought to] be mainly vulnerable to oxidative DNA harm by means of loose radicals, which are thought to play a vital role within all tiers of [cancer formation].” This may be for a number of reasons, which includes “fewer DNA restore enzymes.” Well, the researchers had tissue samples taken earlier than the tomato sauce from biopsies, and tissue samples after the three weeks of tomato sauce from the surgical operation, and resected tissues from tomato sauce-supplemented patients had 28% much less unfastened radical damage than predicted.

Here’s the DNA harm in the prostate before the tomato sauce, and here’s after.

Just 20 days of sauce. And, what’s exciting is that “[t]right here changed into no affiliation among” the extent of lycopene inside the prostate and the protective outcomes.

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Tomatoes include a whole bunch of things, some of which may be even greater effective than lycopene.

Regardless, within assessment to the lycopene dietary supplements alone, “the whole-food intervention” seemed to assist. To see if lycopene played any role in any respect, one could have to check a lycopene-free tomato—within different phrases, a yellow tomato.

So, what in case you in comparison red tomatoes to yellow tomatoes, that have all of the non-lycopene tomato compounds, to instantly lycopene within a pill?

So, they fed human beings crimson tomato paste, yellow tomato paste, lycopene pills, or placebo capsules, after which dripped their blood on prostate most cancers cells growing within a petri dish.

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Compared to the ones no longer consuming whatever, the crimson tomato serum, the blood from those who ate purple tomato paste, significantly decreased the prostate most cancers cellular’s expression of a boom-selling gene known as cyclin D1.

This downregulation of the gene with the aid of the purple tomato intake “may additionally contribute to lower prostate cancer danger with the aid of limiting cell proliferation.” The red tomato regarded to paintings better than the yellow;

so, maybe the lycopene helped, however now not within pill shape. “[T]his gene was no longer regulated by means of [the lycopene-pill serum],” indicating that maybe it’s some thing else.

And, lycopene alone extensively upregulated “procarcinogenic genes.

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