Beta Carotene Before After

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But, lycopene in complement shape doesn’t seem like powerful at decrease doses, both.

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“There is a sturdy [protective] correlation among the intake of [actual whole] fruit[s] and vegetables and the occurrence of certain cancers.” But while we complement with simplest a unmarried compound isolated in tablet shape, we may also disappointed the healthful natural stability of antioxidants. It does appear to be pretty the human hubris to assume we can reproduce “the useful outcomes of ingesting entire fruits and vegetables” through giving dietary supplements of a unmarried phytochemical, which would typically interact with heaps of other compounds within “the herbal matrix” Mother Nature supposed.

In addition to lycopene, other carotenoids in tomatoes encompass beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of which can be recognized “to build up within human prostate tissue.” And, “there are also numerous non–carotenoid compounds in tomatoes that [may] have [anti-cancer] interest”—no longer to say all the compounds we have yet to even signify.

But, it’s now not approximately locating the one magic bullet: “The anti-most cancers outcomes of carotenoids and other phytonutrients may also live in [their] blended hobby.” For instance, on the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene observed in most people who consume regular quantities of tomatoes, there’s little or no effect on most cancers cell growth within vitro, used one after the other.

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But combine them all together, and a non-effective dose plus a non-powerful dose will become effective come what may, extensively suppressing prostate most cancers cell boom.

And, the equal synergy may be visible throughout meals. Curcumin, the yellow pigment in turmeric and curry powder, tomato extracts, and the nutrition E discovered within nuts and seeds do little to inhibit seasoned-increase signaling of prostate most cancers cells—less than 10%.

But all three collectively suppresses growth signaling like 70%.

The entire is greater than the sum of its components.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty- patients with localized prostate [cancer]” had been given three-quarters of a cup of canned tomato sauce every day “for 3 weeks…earlier than their scheduled radical prostatectomy.” In their bloodstream, PSA tiers dropped “by 17.5%.” PSA, prostate-specific antigen, is a protein produced by using prostate gland cells, and extended blood degrees are routinely used “to screen the achievement of [cancer] remedy.

It became surprising to discover that,” in only three weeks, a “tomato sauce-primarily based dietary intervention” ought to lower PSA concentrations in men with prostate cancer. Also, free radical harm of the DNA in their white blood cells dropped by 21%.

Imagine how antioxidant-bad their diet need to had been beforehand, if much less than a cup of tomato sauce a day could reduce DNA damage by means of more than a fifth.

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Okay, but what did they find of their prostates? “[H]uman prostate tissue [is thought to] be in particular liable to oxidative DNA harm through free radicals, which might be notion to play a critical role in all tiers of [cancer formation].” This may be for a number of reasons, which includes “fewer DNA repair enzymes.” Well, the researchers had tissue samples taken earlier than the tomato sauce from biopsies, and tissue samples after the three weeks of tomato sauce from the surgery, and resected tissues from tomato sauce-supplemented sufferers had 28% much less free radical harm than predicted.

Here’s the DNA harm inside the prostate before the tomato sauce, and here’s after.

Just 20 days of sauce. And, what’s exciting is that “[t]here turned into no association among” the extent of lycopene in the prostate and the protective consequences.

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Tomatoes incorporate a whole bunch of factors, some of which may be even more powerful than lycopene.

Regardless, in comparison to the lycopene supplements on my own, “the entire-food intervention” regarded to assist. To see if lycopene played any role in any respect, one could have to check a lycopene-loose tomato—within different words, a yellow tomato.

So, what if you as compared crimson tomatoes to yellow tomatoes, that have all of the non-lycopene tomato compounds, to straight lycopene within a pill?

So, they fed human beings pink tomato paste, yellow tomato paste, lycopene pills, or placebo tablets, after which dripped their blood on prostate most cancers cells growing in a petri dish.

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Compared to those now not consuming anything, the purple tomato serum, the blood from those who ate purple tomato paste, significantly reduced the prostate most cancers mobile’s expression of a increase-selling gene referred to as cyclin D1.

This downregulation of the gene via the red tomato intake “can also make a contribution to decrease prostate cancer chance by limiting mobile proliferation.” The purple tomato seemed to work better than the yellow;

so, perhaps the lycopene helped, however no longer in pill form. “[T]his gene turned into now not regulated through [the lycopene-pill serum],” indicating that perhaps it’s something else.

And, lycopene alone extensively upregulated “procarcinogenic genes.

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