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But, lycopene within complement shape doesn’t appear like powerful at decrease doses, both.

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“There is a strong [protective] correlation among the intake of [actual whole] fruit[s] and veggies and the incidence of sure cancers.” But while we complement with only a unmarried compound isolated within tablet form, we may additionally dissatisfied the healthful natural stability of antioxidants. It does seem to be quite the human hubris to suppose we are able to reproduce “the useful consequences of eating whole culmination and vegetables” by means of giving supplements of a single phytochemical, which might usually engage with thousands of different compounds within “the herbal matrix” Mother Nature supposed.

In addition to lycopene, other carotenoids in tomatoes include beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of that are acknowledged “to accumulate in human prostate tissue.” And, “there also are numerous non–carotenoid compounds in tomatoes that [may] have [anti-cancer] pastime”—not to say all of the compounds we've got yet to even characterize.

But, it’s no longer about locating the only magic bullet: “The anti-cancer effects of carotenoids and other phytonutrients can also are living in [their] combined interest.” For example, at the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene discovered in most of the people who consume everyday amounts of tomatoes, there’s very little impact on most cancers mobile growth in vitro, used one at a time.

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But integrate them all collectively, and a non-powerful dose plus a non-effective dose will become powerful come what may, substantially suppressing prostate cancer mobile growth.

And, the identical synergy may be seen throughout foods. Curcumin, the yellow pigment in turmeric and curry powder, tomato extracts, and the nutrition E discovered within nuts and seeds do little to inhibit seasoned-boom signaling of prostate most cancers cells—less than 10%.

But all three together suppresses growth signaling like 70%.

The whole is extra than the sum of its components.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty- sufferers with localized prostate [cancer]” were given three-quarters of a cup of canned tomato sauce each day “for three weeks…before their scheduled radical prostatectomy.” In their bloodstream, PSA stages dropped “by using 17.5%.” PSA, prostate-specific antigen, is a protein produced by prostate gland cells, and improved blood tiers are mechanically used “to screen the success of [cancer] remedy.

It turned into unexpected to discover that,” in just three weeks, a “tomato sauce-based dietary intervention” ought to decrease PSA concentrations in men with prostate cancer. Also, loose radical damage of the DNA of their white blood cells dropped by 21%.

Imagine how antioxidant-poor their weight-reduction plan ought to were ahead, if much less than a cup of tomato sauce a day should lessen DNA harm through greater than a 5th.

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Okay, however what did they locate of their prostates? “[H]uman prostate tissue [is thought to] be mainly at risk of oxidative DNA harm with the aid of free radicals, which are thought to play a crucial role within all stages of [cancer formation].” This can be for a number of motives, together with “fewer DNA repair enzymes.” Well, the researchers had tissue samples taken earlier than the tomato sauce from biopsies, and tissue samples after the three weeks of tomato sauce from the surgery, and resected tissues from tomato sauce-supplemented sufferers had 28% less unfastened radical harm than anticipated.

Here’s the DNA damage inside the prostate before the tomato sauce, and here’s after.

Just 20 days of sauce. And, what’s exciting is that “[t]here became no association between” the extent of lycopene in the prostate and the protective consequences.

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Tomatoes contain a whole bunch of factors, some of which can be even greater effective than lycopene.

Regardless, in assessment to the lycopene dietary supplements on my own, “the complete-meals intervention” appeared to help. To see if lycopene played any role at all, one could have to test a lycopene-unfastened tomato—in different words, a yellow tomato.

So, what if you compared pink tomatoes to yellow tomatoes, which have all the non-lycopene tomato compounds, to instantly lycopene within a pill?

So, they fed humans pink tomato paste, yellow tomato paste, lycopene pills, or placebo pills, after which dripped their blood on prostate most cancers cells growing within a petri dish.

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Compared to the ones not consuming anything, the crimson tomato serum, the blood from folks that ate pink tomato paste, substantially decreased the prostate cancer cellular’s expression of a increase-promoting gene known as cyclin D1.

This downregulation of the gene via the pink tomato intake “might also make a contribution to decrease prostate cancer chance by restricting mobile proliferation.” The red tomato seemed to work better than the yellow;

so, perhaps the lycopene helped, however no longer within tablet shape. “[T]his gene changed into not regulated through [the lycopene-pill serum],” indicating that maybe it’s some thing else.

And, lycopene on my own drastically upregulated “procarcinogenic genes.

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