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But, lycopene in complement form doesn’t look like powerful at lower doses, both.

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“There is a strong [protective] correlation between the intake of [actual whole] fruit[s] and greens and the occurrence of sure cancers.” But when we supplement with only a unmarried compound remoted within tablet form, we may additionally dissatisfied the wholesome herbal balance of antioxidants. It does appear to be pretty the human hubris to suppose we are able to reproduce “the useful effects of consuming entire fruits and greens” via giving supplements of a unmarried phytochemical, which might normally interact with heaps of other compounds within “the natural matrix” Mother Nature intended.

In addition to lycopene, different carotenoids within tomatoes encompass beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of which are acknowledged “to accumulate in human prostate tissue.” And, “there also are severa non–carotenoid compounds in tomatoes that [may] have [anti-cancer] interest”—not to say all of the compounds we have but to even signify.

But, it’s now not about finding the only magic bullet: “The anti-most cancers outcomes of carotenoids and different phytonutrients may additionally are living within [their] mixed hobby.” For example, on the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene discovered in the majority who devour normal quantities of tomatoes, there’s little or no impact on cancer cell boom within vitro, used separately.

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But integrate them all together, and a non-effective dose plus a non-effective dose will become effective somehow, considerably suppressing prostate most cancers cellular growth.

And, the identical synergy may be seen throughout foods. Curcumin, the yellow pigment within turmeric and curry powder, tomato extracts, and the diet E observed within nuts and seeds do little to inhibit seasoned-boom signaling of prostate cancer cells—much less than 10%.

But all three together suppresses increase signaling like 70%.

The complete is extra than the sum of its components.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty- patients with localized prostate [cancer]” were given three-quarters of a cup of canned tomato sauce every day “for three weeks…before their scheduled radical prostatectomy.” In their bloodstream, PSA tiers dropped “through 17.5%.” PSA, prostate-particular antigen, is a protein produced by means of prostate gland cells, and expanded blood ranges are routinely used “to reveal the achievement of [cancer] remedy.

It was surprising to find that,” in just three weeks, a “tomato sauce-based nutritional intervention” may want to decrease PSA concentrations within guys with prostate most cancers. Also, free radical harm of the DNA of their white blood cells dropped with the aid of 21%.

Imagine how antioxidant-poor their weight-reduction plan have to were beforehand, if much less than a cup of tomato sauce a day may want to reduce DNA damage by more than a fifth.

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Okay, but what did they locate in their prostates? “[H]uman prostate tissue [is thought to] be mainly vulnerable to oxidative DNA harm with the aid of free radicals, which are concept to play a crucial role in all degrees of [cancer formation].” This can be for a number of motives, consisting of “fewer DNA restore enzymes.” Well, the researchers had tissue samples taken before the tomato sauce from biopsies, and tissue samples after the three weeks of tomato sauce from the surgical operation, and resected tissues from tomato sauce-supplemented patients had 28% less loose radical harm than predicted.

Here’s the DNA harm within the prostate before the tomato sauce, and right here’s after.

Just 20 days of sauce. And, what’s interesting is that “[t]right here changed into no association between” the extent of lycopene inside the prostate and the protecting outcomes.

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Tomatoes incorporate an entire bunch of things, some of which may be even extra powerful than lycopene.

Regardless, in evaluation to the lycopene dietary supplements alone, “the complete-food intervention” appeared to assist. To see if lycopene performed any function in any respect, one would have to test a lycopene-free tomato—in different words, a yellow tomato.

So, what if you as compared purple tomatoes to yellow tomatoes, that have all of the non-lycopene tomato compounds, to directly lycopene in a tablet?

So, they fed humans red tomato paste, yellow tomato paste, lycopene drugs, or placebo tablets, after which dripped their blood on prostate cancer cells developing within a petri dish.

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Compared to those not eating some thing, the crimson tomato serum, the blood from individuals who ate crimson tomato paste, notably reduced the prostate cancer cellular’s expression of a growth-promoting gene called cyclin D1.

This downregulation of the gene by way of the red tomato intake “may also contribute to lower prostate most cancers chance with the aid of proscribing cellular proliferation.” The red tomato appeared to paintings higher than the yellow;

so, maybe the lycopene helped, but not in pill shape. “[T]his gene turned into now not regulated via [the lycopene-pill serum],” indicating that perhaps it’s something else.

And, lycopene on my own substantially upregulated “procarcinogenic genes.

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