Author: Dean Rouseberg
Time for reading: ~4
minutes
Last Updated:
August 08, 2022
Learn more information about foods high in lycopene. In this article we'll discuss foods high in lycopene.
But, lycopene in supplement form doesn’t seem like effective at decrease doses, both.
In addition to lycopene, different carotenoids in tomatoes encompass beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of which are known “to build up in human prostate tissue.” And, “there are also numerous non–carotenoid compounds in tomatoes that [may] have [anti-cancer] interest”—now not to mention all of the compounds we've yet to even represent.
But, it’s now not about locating the one magic bullet: “The anti-cancer consequences of carotenoids and different phytonutrients may reside in [their] blended interest.” For instance, on the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene determined within the general public who devour everyday quantities of tomatoes, there’s very little impact on cancer mobile growth in vitro, used one after the other.But integrate them all together, and a non-powerful dose plus a non-effective dose becomes powerful by hook or by crook, significantly suppressing prostate most cancers mobile growth.
And, the equal synergy can be visible across foods. Curcumin, the yellow pigment within turmeric and curry powder, tomato extracts, and the vitamin E located in nuts and seeds do little to inhibit pro-increase signaling of prostate most cancers cells—much less than 10%.But all three together suppresses increase signaling like 70%.
The complete is more than the sum of its parts.So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?
“Thirty-two sufferers with localized prostate [cancer]” were given three-quarters of a cup of canned tomato sauce each day “for 3 weeks…earlier than their scheduled radical prostatectomy.” In their bloodstream, PSA tiers dropped “by means of 17.5%.” PSA, prostate-specific antigen, is a protein produced with the aid of prostate gland cells, and improved blood degrees are robotically used “to reveal the success of [cancer] treatment.
It turned into surprising to locate that,” in just three weeks, a “tomato sauce-based nutritional intervention” may want to lower PSA concentrations in guys with prostate cancer. Also, unfastened radical damage of the DNA in their white blood cells dropped by way of 21%.Imagine how antioxidant-poor their weight-reduction plan have to had been in advance, if much less than a cup of tomato sauce an afternoon may want to lessen DNA harm via greater than a 5th.
Okay, however what did they discover in their prostates? “[H]uman prostate tissue [is thought to] be particularly susceptible to oxidative DNA damage by unfastened radicals, which might be thought to play a important position in all stages of [cancer formation].” This can be for a number of motives, along with “fewer DNA repair enzymes.” Well, the researchers had tissue samples taken earlier than the tomato sauce from biopsies, and tissue samples after the 3 weeks of tomato sauce from the surgical procedure, and resected tissues from tomato sauce-supplemented patients had 28% less loose radical damage than anticipated.Here’s the DNA damage in the prostate earlier than the tomato sauce, and right here’s after.
Just 20 days of sauce. And, what’s interesting is that “[t]here turned into no affiliation among” the level of lycopene within the prostate and the protecting results.Tomatoes comprise a whole bunch of factors, some of which may be even extra powerful than lycopene.
Regardless, in evaluation to the lycopene supplements on my own, “the entire-meals intervention” regarded to help. To see if lycopene played any role in any respect, one might have to check a lycopene-free tomato—in different words, a yellow tomato.So, what if you compared red tomatoes to yellow tomatoes, that have all the non-lycopene tomato compounds, to immediately lycopene within a pill?
So, they fed people purple tomato paste, yellow tomato paste, lycopene pills, or placebo drugs, after which dripped their blood on prostate cancer cells developing within a petri dish. Compared to those no longer ingesting whatever, the pink tomato serum, the blood from those who ate crimson tomato paste, extensively decreased the prostate cancer cell’s expression of a growth-promoting gene known as cyclin D1.This downregulation of the gene via the red tomato intake “can also make contributions to lower prostate cancer threat through proscribing mobile proliferation.” The red tomato appeared to work better than the yellow;
so, perhaps the lycopene helped, but now not in pill form. “[T]his gene became not regulated with the aid of [the lycopene-pill serum],” indicating that maybe it’s some thing else.And, lycopene on my own appreciably upregulated “procarcinogenic genes.