Free Radicals And Antioxidants

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But, lycopene within supplement form doesn’t look like powerful at lower doses, either.

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“There is a strong [protective] correlation among the consumption of [actual whole] fruit[s] and greens and the incidence of positive cancers.” But while we complement with most effective a single compound isolated within pill form, we may additionally dissatisfied the wholesome natural stability of antioxidants. It does appear to be quite the human hubris to suppose we are able to reproduce “the beneficial consequences of eating whole end result and vegetables” by giving dietary supplements of a single phytochemical, which could commonly interact with hundreds of different compounds in “the natural matrix” Mother Nature supposed.

In addition to lycopene, other carotenoids in tomatoes include beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of which might be known “to accumulate in human prostate tissue.” And, “there are also numerous non–carotenoid compounds within tomatoes that [may] have [anti-cancer] activity”—not to say all of the compounds we've got yet to even signify.

But, it’s not about locating the only magic bullet: “The anti-cancer results of carotenoids and other phytonutrients might also reside within [their] combined interest.” For instance, at the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene observed within most of the people who devour regular quantities of tomatoes, there’s little or no impact on most cancers cellular growth within vitro, used one by one.

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But integrate them all together, and a non-powerful dose plus a non-effective dose turns into powerful somehow, substantially suppressing prostate cancer cellular increase.

And, the identical synergy may be seen across ingredients. Curcumin, the yellow pigment within turmeric and curry powder, tomato extracts, and the nutrition E found in nuts and seeds do little to inhibit pro-boom signaling of prostate most cancers cells—much less than 10%.

But all three collectively suppresses growth signaling like 70%.

The whole is more than the sum of its components.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty-two patients with localized prostate [cancer]” had been given three-quarters of a cup of canned tomato sauce each day “for three weeks…before their scheduled radical prostatectomy.” In their bloodstream, PSA degrees dropped “through 17.5%.” PSA, prostate-precise antigen, is a protein produced with the aid of prostate gland cells, and accelerated blood degrees are routinely used “to reveal the success of [cancer] remedy.

It was sudden to find that,” in just three weeks, a “tomato sauce-based totally nutritional intervention” should decrease PSA concentrations in men with prostate cancer. Also, loose radical harm of the DNA in their white blood cells dropped by way of 21%.

Imagine how antioxidant-negative their eating regimen have to were ahead, if much less than a cup of tomato sauce a day ought to lessen DNA damage by using greater than a fifth.

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Okay, but what did they discover of their prostates? “[H]uman prostate tissue [is thought to] be particularly prone to oxidative DNA damage through unfastened radicals, which might be thought to play a important role within all levels of [cancer formation].” This can be for a number of motives, along with “fewer DNA repair enzymes.” Well, the researchers had tissue samples taken before the tomato sauce from biopsies, and tissue samples after the 3 weeks of tomato sauce from the surgical procedure, and resected tissues from tomato sauce-supplemented patients had 28% much less loose radical harm than anticipated.

Here’s the DNA harm inside the prostate before the tomato sauce, and right here’s after.

Just 20 days of sauce. And, what’s thrilling is that “[t]here became no affiliation among” the extent of lycopene in the prostate and the protective effects.

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Tomatoes contain a whole bunch of things, a number of which may be even more powerful than lycopene.

Regardless, in comparison to the lycopene supplements by myself, “the complete-food intervention” appeared to assist. To see if lycopene played any function in any respect, one could have to test a lycopene-unfastened tomato—in different words, a yellow tomato.

So, what if you in comparison pink tomatoes to yellow tomatoes, which have all the non-lycopene tomato compounds, to straight lycopene within a pill?

So, they fed people red tomato paste, yellow tomato paste, lycopene capsules, or placebo pills, and then dripped their blood on prostate most cancers cells growing in a petri dish.

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Compared to the ones now not ingesting anything, the crimson tomato serum, the blood from folks who ate red tomato paste, appreciably decreased the prostate cancer mobile’s expression of a growth-selling gene known as cyclin D1.

This downregulation of the gene by the red tomato consumption “may also make a contribution to decrease prostate cancer hazard by restricting mobile proliferation.” The pink tomato appeared to paintings better than the yellow;

so, maybe the lycopene helped, but now not within pill form. “[T]his gene became no longer regulated via [the lycopene-pill serum],” indicating that maybe it’s some thing else.

And, lycopene alone considerably upregulated “procarcinogenic genes.

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